Antioxidative and anti-inflammatory activity of psiguadial B and its halogenated analogues as potential neuroprotective agents

被引：2

作者：

Kadayat, Tara Man ^{[1
]}

Kim, Dong Eun ^{[2
]}

Lee, Sang Bong ^{[3
]}

Jung, Kyungjin ^{[1
]}

Park, Sang Eun ^{[2
]}

Hong, Ji-Ye ^{[2
]}

Kim, Jina ^{[1
]}

Shrestha, Aarajana ^{[1
]}

Kim, Dong-Su ^{[4
]}

An, Hongchan ^{[1
]}

Kim, Nayeon ^{[1
]}

Lee, Su-Jeong ^{[1
]}

Kwon, Sugyeong ^{[1
]}

Kim, Suhui ^{[1
]}

Hwang, Jun Yeon ^{[1
]}

Kim, Shinae ^{[1
]}

Hahn, Dongyup ^{[5
]}

Choi, Hyukjae ^{[6
]}

Nam, Sang-Jip ^{[7
]}

Jeon, Yong Hyun ^{[8
]}

Hwang, Jung Jin ^{[2
,9
]}

Cho, Sung Jin ^{[10
]}

Chin, Jungwook ^{[1
]}

机构：

[1] Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu 41061, South Korea

[2] Asan Med Ctr, Asan Inst Life Sci, Seoul 05505, South Korea

[3] Gyeongbuk Inst Bio Ind, Vaccine Commercializat Ctr, Andong 33618, South Korea

[4] Korea Res Inst Chem Technol, Therapeut & Biotechnol Div, Daejeon 34114, South Korea

[5] Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea

[6] Yeungnam Univ, Coll Pharm, Gyeongbuk 38541, South Korea

[7] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea

[8] Daegu Gyeongbuk Med Innovat Fdn, Lab Anim Ctr, Daegu 41061, South Korea

[9] Univ Ulsan, Asan Med Ctr, Dept Convergence Med, Coll Med, Seoul 05505, South Korea

[10] Korea Inst Sci & Technol, Convergence Res Ctr Diag Treatment & Care Syst De, Seoul 02792, South Korea

来源：

BIOORGANIC CHEMISTRY | 2021年 / 113卷

基金：

新加坡国家研究基金会;

关键词：

Psiguadial B; Reactive oxygen species; Antioxidative effect; Anti-inflammatory effect; Neuroprotective agent; Short synthetic route; 3 UNUSUAL MEROTERPENOIDS; PSIDIUM-GUA[!text type='JAVA']JAVA[!/text] L; NEURODEGENERATIVE DISEASES; BIOMIMETIC SYNTHESIS; OXIDATIVE STRESS; LEAVES; EXTRACTS;

D O I：

10.1016/j.bioorg.2021.105027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Psiguadial B (8), and its fluoro- (8a), chloro- (8b), and bromo- (8c) derivatives were synthesized using a sodium acetate-catalyzed single step coupling of three components: beta-caryophyllene (5), diformylphloroglucinol (11), and benzaldehyde (12). These compounds efficiently and dose-dependently decreased H2O2-induced cell death, a quantitative marker of cell death, in primary cultures of mouse cortical neurons. Psiguadial B also decreased neuronal death and accumulation of ROS induced by FeCl2 in cortical cultures. The in vitro effects of these compounds in lipopolysaccharide (LPS)-induced expression of nitric oxide (NO), and TNF-alpha and IL-6 by suppressing the NF-kappa B pathway in immune cells demonstrated their antioxidative and anti-inflammatory activity. The present findings warrant further research on the development of psiguadial B-based neuroprotective agents for the treatment of neurodegenerative diseases, acute brain injuries and immunological disorders.

引用

页数：10

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