Antioxidative and anti-inflammatory activity of psiguadial B and its halogenated analogues as potential neuroprotective agents

被引：2

作者：

Kadayat, Tara Man ^{[1
]}

Kim, Dong Eun ^{[2
]}

Lee, Sang Bong ^{[3
]}

Jung, Kyungjin ^{[1
]}

Park, Sang Eun ^{[2
]}

Hong, Ji-Ye ^{[2
]}

Kim, Jina ^{[1
]}

Shrestha, Aarajana ^{[1
]}

Kim, Dong-Su ^{[4
]}

An, Hongchan ^{[1
]}

Kim, Nayeon ^{[1
]}

Lee, Su-Jeong ^{[1
]}

Kwon, Sugyeong ^{[1
]}

Kim, Suhui ^{[1
]}

Hwang, Jun Yeon ^{[1
]}

Kim, Shinae ^{[1
]}

Hahn, Dongyup ^{[5
]}

Choi, Hyukjae ^{[6
]}

Nam, Sang-Jip ^{[7
]}

Jeon, Yong Hyun ^{[8
]}

Hwang, Jung Jin ^{[2
,9
]}

Cho, Sung Jin ^{[10
]}

Chin, Jungwook ^{[1
]}

机构：

[1] Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu 41061, South Korea

[2] Asan Med Ctr, Asan Inst Life Sci, Seoul 05505, South Korea

[3] Gyeongbuk Inst Bio Ind, Vaccine Commercializat Ctr, Andong 33618, South Korea

[4] Korea Res Inst Chem Technol, Therapeut & Biotechnol Div, Daejeon 34114, South Korea

[5] Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea

[6] Yeungnam Univ, Coll Pharm, Gyeongbuk 38541, South Korea

[7] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea

[8] Daegu Gyeongbuk Med Innovat Fdn, Lab Anim Ctr, Daegu 41061, South Korea

[9] Univ Ulsan, Asan Med Ctr, Dept Convergence Med, Coll Med, Seoul 05505, South Korea

[10] Korea Inst Sci & Technol, Convergence Res Ctr Diag Treatment & Care Syst De, Seoul 02792, South Korea

来源：

BIOORGANIC CHEMISTRY | 2021年 / 113卷

基金：

新加坡国家研究基金会;

关键词：

Psiguadial B; Reactive oxygen species; Antioxidative effect; Anti-inflammatory effect; Neuroprotective agent; Short synthetic route; 3 UNUSUAL MEROTERPENOIDS; PSIDIUM-GUA[!text type='JAVA']JAVA[!/text] L; NEURODEGENERATIVE DISEASES; BIOMIMETIC SYNTHESIS; OXIDATIVE STRESS; LEAVES; EXTRACTS;

D O I：

10.1016/j.bioorg.2021.105027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Psiguadial B (8), and its fluoro- (8a), chloro- (8b), and bromo- (8c) derivatives were synthesized using a sodium acetate-catalyzed single step coupling of three components: beta-caryophyllene (5), diformylphloroglucinol (11), and benzaldehyde (12). These compounds efficiently and dose-dependently decreased H2O2-induced cell death, a quantitative marker of cell death, in primary cultures of mouse cortical neurons. Psiguadial B also decreased neuronal death and accumulation of ROS induced by FeCl2 in cortical cultures. The in vitro effects of these compounds in lipopolysaccharide (LPS)-induced expression of nitric oxide (NO), and TNF-alpha and IL-6 by suppressing the NF-kappa B pathway in immune cells demonstrated their antioxidative and anti-inflammatory activity. The present findings warrant further research on the development of psiguadial B-based neuroprotective agents for the treatment of neurodegenerative diseases, acute brain injuries and immunological disorders.

引用

页数：10

共 50 条

[21] METHODS OF SYNTHESIS OF QUINAZOLINES AND THEIR CONDENSED ANALOGUES-POTENTIAL ANTI-INFLAMMATORY AGENTS (REVIEW)
Krasovska, Natalya I.
Koptieva, Svitlana D.
Posudiievska, Olha R.
Kyrylakha, Svitlana V.
Vosokoboynik, Oleksiy Yu.
Okovytyy, Sergiy I.
Kovalenko, Serhiy I.
JOURNAL OF CHEMISTRY AND TECHNOLOGIES, 2023, 31 (02): : 385 - 410
[22] Curcumin analogues as possible anti-proliferative & anti-inflammatory agents
Katsori, A. -M.
Chatzopoulou, M.
Dimas, K.
Kontogiorgis, C.
Patsilinakos, A.
Trangas, T.
Hadjipavlou-Litina, D.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (07) : 2722 - 2735
[23] Novel Anti-Inflammatory and Neuroprotective Agents for Parkinson's Disease
Lu, Li
Li, Fengqiao
Wang, Xiaomin
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2010, 9 (02) : 232 - 240
[24] Synthesis and biological activity of new phthalimides as potential anti-inflammatory agents
Bach, Duc-Hiep
Liu, Jian-Yu
Kim, Won Kyung
Hong, Ji-Young
Park, So Hyun
Kim, Donghwa
Qin, Si-Ning
Luu, Thi-Thu-Trang
Park, Hyen Joo
Xu, Yong-Nan
Lee, Sang Kook
BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 25 (13) : 3396 - 3405
[25] Antidiabetic agents: Potential anti-inflammatory activity beyond glucose control
Scheen, A. J.
Esser, N.
Paquot, N.
DIABETES & METABOLISM, 2015, 41 (03) : 183 - 194
[26] Late Breaking Abstract - Anti-inflammatory activity of novel transtilbene sulfonamide analogues as potential novel therapeutic agents for inflammatory lung disease
Mahendran, Rhamiya
Bassin, Paul
Cook, Mike
Rossiter, Sharon
Martin, Abigail
Hutter, Victoria
EUROPEAN RESPIRATORY JOURNAL, 2019, 54
[27] ANTI-INFLAMMATORY ACTIVITY OF NOVEL TRANS-STILBENE SULFONAMIDE ANALOGUES AS POTENTIAL NOVEL THERAPEUTIC AGENTS FOR LUNG DISEASE
Mahendran, R.
Osoba, E.
Rossiter, S.
Bassin, J. P.
Cook, M. T.
Hutter, V.
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 2017, 30 (04) : A21 - A21
[28] Anti-Inflammatory Activity of the Compositae Family and Its Therapeutic Potential
Xavier Paes Lopes, Deise Cristina Drummond
de Oliveira, Temistocles Barroso
Vicosa, Alessandra Lifsitch
Valverde, Simone Sacramento
Ricci Junior, Eduardo
PLANTA MEDICA, 2021, 87 (01/02) : 71 - 100
[29] New analogues of butylated hydroxytoluene as anti-inflammatory and antioxidant agents
Ziakas, George N.
Rekka, Eleni A.
Gavalas, Antonios M.
Eleftheriou, Phaedra T.
Kourounakis, Panos N.
BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (16) : 5616 - 5624
[30] Does conjugation of antioxidants improve their antioxidative/anti-inflammatory potential?
Hadjipavlou-Litina, Dimitra
Magoulas, George E.
Bariamis, Stavros E.
Drainas, Denis
Avgoustakis, Konstantinos
Papaioannou, Dionissios
BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 18 (23) : 8204 - 8217

← 1 2 3 4 5 →