Synthesis of licochalcone analogues with increased anti-inflammatory activity

被引：29
|
作者：
Kim, Si-Jun [1 ,2 ]
Kim, Cheol Gi [1 ,2 ]
Yun, So-Ra [1 ,2 ]
Kim, Jin-Kyung [3 ]
Jun, Jong-Gab [1 ,2 ]
机构：
[1] Hallym Univ, Dept Chem, Chunchon 200702, South Korea
[2] Hallym Univ, Inst Appl Chem, Chunchon 200702, South Korea
[3] Catholic Univ Daegu, Coll Nat Sci, Dept Biomed Sci, Gyeungsan Si 700702, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
Licohalcone B; Licohalcone D; 3,3]-Sigmatropic rearrangement; anti-Inflammatory effects; IC50 values of NO production; PHENOLIC CONSTITUENTS; LICORICE; FLAVONOIDS; CHALCONES;
D O I：
10.1016/j.bmcl.2013.11.044
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Licohalcones have been reported to have various biological activities. However, most of licochalcones also showed cytotoxicity even though their versitile utilities. Licochalcones B and D, which have common substituents at aromatic ring B, are targeted to modify the structure at aromatic ring A for inflammatory studies. Licochalcone derivatives (1-6) thus prepared are compared for their suppression ability of nitric oxide (NO) production and showed 9.94, 4.72, 10.1, 4.85, 2.37 and 4.95 mu M of IC50 values, respectively. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：181 / 185
页数：5
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