Synthesis of licochalcone analogues with increased anti-inflammatory activity

被引：29

作者：

Kim, Si-Jun ^{[1
,2
]}

Kim, Cheol Gi ^{[1
,2
]}

Yun, So-Ra ^{[1
,2
]}

Kim, Jin-Kyung ^{[3
]}

Jun, Jong-Gab ^{[1
,2
]}

机构：

[1] Hallym Univ, Dept Chem, Chunchon 200702, South Korea

[2] Hallym Univ, Inst Appl Chem, Chunchon 200702, South Korea

[3] Catholic Univ Daegu, Coll Nat Sci, Dept Biomed Sci, Gyeungsan Si 700702, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Licohalcone B; Licohalcone D; 3,3]-Sigmatropic rearrangement; anti-Inflammatory effects; IC50 values of NO production; PHENOLIC CONSTITUENTS; LICORICE; FLAVONOIDS; CHALCONES;

D O I：

10.1016/j.bmcl.2013.11.044

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Licohalcones have been reported to have various biological activities. However, most of licochalcones also showed cytotoxicity even though their versitile utilities. Licochalcones B and D, which have common substituents at aromatic ring B, are targeted to modify the structure at aromatic ring A for inflammatory studies. Licochalcone derivatives (1-6) thus prepared are compared for their suppression ability of nitric oxide (NO) production and showed 9.94, 4.72, 10.1, 4.85, 2.37 and 4.95 mu M of IC50 values, respectively. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：181 / 185

页数：5

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