Synthesis of licochalcone analogues with increased anti-inflammatory activity

被引：29

作者：

Kim, Si-Jun ^{[1
,2
]}

Kim, Cheol Gi ^{[1
,2
]}

Yun, So-Ra ^{[1
,2
]}

Kim, Jin-Kyung ^{[3
]}

Jun, Jong-Gab ^{[1
,2
]}

机构：

[1] Hallym Univ, Dept Chem, Chunchon 200702, South Korea

[2] Hallym Univ, Inst Appl Chem, Chunchon 200702, South Korea

[3] Catholic Univ Daegu, Coll Nat Sci, Dept Biomed Sci, Gyeungsan Si 700702, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Licohalcone B; Licohalcone D; 3,3]-Sigmatropic rearrangement; anti-Inflammatory effects; IC50 values of NO production; PHENOLIC CONSTITUENTS; LICORICE; FLAVONOIDS; CHALCONES;

D O I：

10.1016/j.bmcl.2013.11.044

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Licohalcones have been reported to have various biological activities. However, most of licochalcones also showed cytotoxicity even though their versitile utilities. Licochalcones B and D, which have common substituents at aromatic ring B, are targeted to modify the structure at aromatic ring A for inflammatory studies. Licochalcone derivatives (1-6) thus prepared are compared for their suppression ability of nitric oxide (NO) production and showed 9.94, 4.72, 10.1, 4.85, 2.37 and 4.95 mu M of IC50 values, respectively. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：181 / 185

页数：5

共 50 条

[21] Synthesis and anti-inflammatory activity of isoquebecol
Cardinal, Sebastien
Paquet-Cote, Pierre-Alexandre
Azelmat, Jabrane
Bouchard, Corinne
Grenier, Daniel
Voyer, Normand
BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 25 (07) : 2043 - 2056
[22] Design, Synthesis and In-vivo Anti-inflammatory Activity of New Celecoxib Analogues as NSAID
Hafez, Naglaa A. Abdel
Ali, Korany A.
Ibrahim, Alhussein A.
Elnaggar, Dina H.
Sleem, Amany A.
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2018, 18 (16) : 1398 - 1408
[23] Synthesis and anti-inflammatory activity of ethynylthiazoles
Geronikaki, A.
Vasilevsky, S.
Hadjipavlou-Litina, D.
Lagunin, A.
Poroikov, B. V.
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 2006, (05): : 769 - 774
[24] Synthesis and anti-inflammatory activity of steroidal
Pathak, D
Jindal, DP
ASIAN JOURNAL OF CHEMISTRY, 1998, 10 (04) : 813 - 817
[25] Synthesis and Anti-Inflammatory Activity of Pyrazolines
Ramesh, B.
Sumana, T.
E-JOURNAL OF CHEMISTRY, 2010, 7 (02) : 514 - 516
[26] Total synthesis and anti-inflammatory evaluation of violacin A and its analogues
Liu, Qingyin
Mu, Yu
An, Qi
Xun, Jiali
Ma, Jian
Wu, Wenxi
Xu, Minjuan
Xu, Jun
Han, Li
Huang, Xueshi
BIOORGANIC CHEMISTRY, 2020, 94
[27] Synthesis, crystal structure and anti-inflammatory properties of curcumin analogues
Liang, Guang
Yang, Shulin
Zhou, Huiping
Shao, Lili
Huang, Kexin
Xiao, Jian
Huang, Zhifeng
Li, Xiaokun
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (02) : 915 - 919
[28] Total Synthesis and Anti-Inflammatory Evaluation of Osajin, Scandenone and Analogues
Wang, Rui
Ma, Ran
Feng, Ke
Lu, Hongchen
Zhao, Wei
Jin, Hongzhen
PHARMACEUTICALS, 2024, 17 (01)
[29] Synthesis and Anti-Inflammatory Activity of the Natural Cyclooxygenase-2 Inhibitor Axinelline A and Its Analogues
Ju, Zhiran
Shang, Ziyi
Mahmud, Taifo
Fang, Jingjie
Liu, Yonghong
Pan, Qidong
Lin, Xiuping
Chen, Fener
JOURNAL OF NATURAL PRODUCTS, 2023, 86 (04): : 958 - 965
[30] Design, synthesis and anti-inflammatory activity study of lansiumamide analogues for treatment of acute lung injury
Song, Liyan
Li, Gang
Guan, Wen
Zeng, Zhijun
Ou, Yanghui
Zhao, Tongchao
Li, Jiayu
He, Dengqin
Fang, Xiangxiang
Zhang, Yali
Wu, Jia-qiang
Tong, Rongbiao
Yao, Hongliang
BIOMEDICINE & PHARMACOTHERAPY, 2023, 166

← 1 2 3 4 5 →