Synthesis and anti-inflammatory activity of ethynylthiazoles

被引：0
|
作者：
Geronikaki, A. [1 ]
Vasilevsky, S.
Hadjipavlou-Litina, D.
Lagunin, A.
Poroikov, B. V.
机构：
[1] Aristotle Univ Thessaloniki, Sch Pharm, Thessaloniki 54124, Greece
[2] Russian Acad Sci, Siberian Branch, Inst Chem Kinet & Combust, Novosibirsk 630090, Russia
[3] RAMS, VN Orekhnovich Inst Biomed Chem, Moscow 119992, Russia
来源：
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII | 2006年 / 05期
关键词：
ethynyl thiazoles; lipoxygenase (LOX); anti-inflammatory;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of acetylene derivatives of thiazole using Sonogashira cross-coupling method was synthesized and evaluated in vivo for their anti-inflammatory activity. Four compounds exhibited a good anti-inflammatory activity and two inhibited soybean lipoxygenase.
引用
收藏
页码：769 / 774
页数：6
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