The presence of anti-phosphatidylserine/prothrombin antibodies as risk factor for both arterial and venous thrombosis in patients with systemic lupus erythematosus

被引：1
|
作者：
Nojima, Junzo [1 ]
Iwatani, Yoshinori [2 ]
Suehisa, Etsuji [1 ]
Kuratsune, Hirohiko [3 ]
Kanakura, Yuzuru [4 ]
机构：
[1] Osaka Univ Hosp, Lab Clin Invest, Suita, Osaka 5650871, Japan
[2] Osaka Univ, Div Biomed Informat, Course Hlth Sci, Grad Sch Med, Suita, Osaka, Japan
[3] Kansai Univ Welf Sci, Fac Hlth Sci Welf, Dept Hlth Sci, Osaka 5820026, Japan
[4] Osaka Univ, Dept Hematol & Oncol, Grad Sch Med, Suita, Osaka, Japan
来源：
HAEMATOLOGICA | 2006年 / 91卷 / 05期
关键词：
anti-phospholipid antibodies; systemic lupus erythematosus; anti-beta 2-glycoprotein I antibodies; anti-phosphatidylserine/prothrombin antibodies;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In an effort to clarify the clinical significance of anti-phospholipid antibodies (aPL) detected by enzyme-linked immunosorbent assay (ELISA), we examined the prevalence of anti-cardiolipin antibodies (aCL), anti-beta 2-glycoprotein I antibodies (anti-beta 2-GPI), anti-prothrombin antibodies (anti-PT), and anti-phosphatidylserine/prothrombin antibodies (anti-PS/PT) in 175 patients with systemic lupus erythematosus (SLE) comprising 67 patients with thrombotic complications. The present study showed that positive results of anti-beta 2-GPI-ELISA and anti-PS/PT-ELISA could serve as markers of thrombotic complications in patients with SLE, whereas aCL and anti-PT are less reliable as markers of these complications. Furthermore, results of the anti-PS/PT-ELISA correlate best with the occurrence of both arterial and venous thrombosis in patients with SLE.
引用
收藏
页码：699 / 702
页数：4
相关论文
共 50 条
  • [31] Transiently positive anticardiolipin antibodies and risk of thrombosis in patients with systemic lupus erythematosus
    Martincz-Berriotxoa, Agustin
    Ruiz-Rastorza, Guillermo
    Egurbide, Maria-Victoria
    Garmendia, Maider
    Erdozain, Jose Gabriel
    Villar, Irama
    Aguirre, Ciriaco
    LUPUS, 2007, 16 (10) : 810 - 816
  • [32] Risk for venous thrombosis related to antiphospholipid antibodies in systemic lupus erythematosus - A meta-analysis
    Wahl, DG
    Guillemin, F
    deMaistre, E
    Perret, C
    Lecompte, T
    Thibaut, G
    LUPUS, 1997, 6 (05) : 467 - 473
  • [33] IgG phosphatidylserine/prothrombin antibodies as a risk factor of thrombosis in antiphospholipid antibody carriers
    Tonello, Marta
    Mattia, Elena
    Favaro, Maria
    Del Ross, Teresa
    Calligaro, Antonia
    Salvan, Elisa
    Hoxha, Ariela
    Fedrigo, Marny
    Ruffatti, Amelia
    THROMBOSIS RESEARCH, 2019, 177 : 157 - 160
  • [34] A case of catastrophic antiphospholipid antibody syndrome complicated with systemic lupus erythematosus, double positive for anti-cardiolipin/β2 glycoprotein I and anti-phosphatidylserine/prothrombin autoantibodies
    Hirakawa, Eri
    Saito, Kazuyoshi
    Hirata, Shintaro
    Atsumi, Tatsuya
    Koike, Takao
    Tanaka, Yoshiya
    MODERN RHEUMATOLOGY, 2012, 22 (05) : 769 - 773
  • [35] The presence of anti-beta(2)-glycoprotein I and anti-prothrombin antibodies and their correlations with venous and arterial thrombosis
    Horbach, DA
    Derksen, RHWM
    DeGroot, PG
    ANNALES DE MEDECINE INTERNE, 1996, 147 : 42 - 43
  • [36] ANTICARDIOLIPIN ANTIBODIES - A RISK FACTOR FOR VENOUS AND ARTERIAL THROMBOSIS
    不详
    LANCET, 1985, 1 (8434): : 912 - 913
  • [37] Anti-Phosphatidylethanolamine and Anti-Phosphatidylserine Antibodies-Association with Renal Involvement, Atherosclerosis, Cardiovascular Manifestations, Raynaud Phenomenon and Disease Activity in Polish Patients with Systemic Lupus Erythematosus
    Fischer, Katarzyna
    Przepiera-Bedzak, Hanna
    Brzosko, Iwona
    Sawicki, Marcin
    Walecka, Anna
    Brzosko, Marek
    BIOMOLECULES, 2022, 12 (10)
  • [38] The association between anti-phosphatidylserine/prothrombin antibodies (aPS/PT) and epidermal growth factor (EGF) in patients with recurrent pregnancy loss
    Yoshihiro, Sato
    Toshitaka, Sugi
    JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2022, 153
  • [39] Arterial and venous thrombosis: A case of Antiphospholipid Syndrome in Systemic Lupus Erythematosus.
    Forbes, TD
    Safran, ES
    JOURNAL OF GENERAL INTERNAL MEDICINE, 2002, 17 : 40 - 40
  • [40] The relationship between anti-phosphatidylserine/prothrombin complex IgM antibodies and cutaneous ulcers in patients with cutaneous vasculitis
    Kawakami, Tamihiro
    Okiyama, Naoko
    Kodera, Masanari
    Seishima, Mariko
    Yamaguchi, Yukie
    JOURNAL OF DERMATOLOGY, 2021, 48 (09): : 1457 - 1458
12345