Transiently positive anticardiolipin antibodies and risk of thrombosis in patients with systemic lupus erythematosus

被引:52
|
作者
Martincz-Berriotxoa, Agustin [1 ]
Ruiz-Rastorza, Guillermo [1 ]
Egurbide, Maria-Victoria [1 ]
Garmendia, Maider [1 ]
Erdozain, Jose Gabriel [1 ]
Villar, Irama [1 ]
Aguirre, Ciriaco [1 ]
机构
[1] Univ Basque Country, Euskal Herriko Univ, Hosp Cruces, Serv Internal Med, Bizkaia, Basque County, Spain
关键词
antiphospholipid antibodies; lupus anticoagulant; anticardiolipin antibodies; systemic lupus erythematosus; thrombosis;
D O I
10.1177/0961203307083316
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Fluctuations in the titers of anticarcholipin antibodies (aCL) have been reported in systemic lupus erythematosus (SLE) patients, but their relation with thrombosis is not completely understood. Prospective inception cohort of 237 patients with SLE (American College of Rheumatology criteria). Positivity for antiphospholipid antibodies (aPL) was defined according to Sapporo criteria. aCL was defined as persistently positive when more than two-thirds of the determinations were positive during follow-up. Patients were classified into four groups: A [positive lupus anticoagulant (LA)], B (negative LA and persistently positive aCL), C (negative LA and transiently positive aCL) and D (negative LA and aCL). Of these 237 patients, 211 (89%) patients were women. Median age at diagnosis and follow-up were 32 (2-78) and 10 (1-31) years, respectively: 33 (13.9%) 23 (9.7%) 42 (17.7%) and 139 (58.6%) patients were classified in groups A, B, C and D, respectively. Thirty (12.6%) and 23 (9.7%) patients suffered arterial and venous thrombotic events, respectively. Adjusted risk for arterial thrombosis was increased in groups A [odds ratio (OR) 15.69, 95% confidential interval (CI) 4.79-51.42, P < 0.001] and B (OR 7.63, 95% Cl 2.00-29.08, P = 0.003), but not in Group C when compared with group D. Adjusted risk of venous thrombosis was increased in group A (OR 4.24 95% CI 1.36-13.20 P = 0.013). but not in Groups B or C when compared with group D. Risk of thrombosis is not increased in SLE patients with negative LA and transiently positive aCL, even fulfilling Sapporo laboratory criteria, when compared with aPL-negative SLE patients.
引用
收藏
页码:810 / 816
页数:7
相关论文
共 50 条
  • [1] Transiently positive anticardiolipin antibodies do not increase the risk of thrombosis in patients with systemic lupus erythematosus
    Martinez-Berriotxoa, A.
    Ruiz-Irastorza, G.
    Egurbide, M. V.
    Garmendia, M.
    Erdozain, J. G.
    Villar, I.
    Aguirre, C.
    [J]. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2007, 25 (02) : 129 - 129
  • [2] Clinical significance of transiently positive anticardiolipin antibodies in patients with systemic lupus erythematosus
    Martinez-Berriotxoa, A.
    Ruiz-Irastorza, G.
    Egurbide, M.
    Garmendia, M.
    Erdozain, J.
    Villar, I.
    Aguirre, C.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 : 471 - 472
  • [3] ANTICARDIOLIPIN ANTIBODIES AND THROMBOSIS IN SYSTEMIC LUPUS-ERYTHEMATOSUS
    KRAJNC, I
    ADAMCIC, M
    [J]. ZDRAVSTVENI VESTNIK, 1986, 55 (7-8): : 345 - 347
  • [4] ANTICARDIOLIPIN ANTIBODIES IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS
    STURFELT, G
    NIVED, O
    NORBERG, R
    THORSTENSSON, R
    KROOK, K
    [J]. ARTHRITIS AND RHEUMATISM, 1987, 30 (04): : 382 - 388
  • [5] ANTICARDIOLIPIN ANTIBODIES IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS
    SMEENK, R
    LUCASSEN, W
    VANROOIJEN, A
    SWAAK, T
    [J]. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 1988, 6 (02) : 212 - 212
  • [6] METHODOLOGICAL APPROACH FOR THE DETECTION OF ANTICARDIOLIPIN ANTIBODIES IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS AND THROMBOSIS
    RUPIN, A
    GRUEL, Y
    WATIER, H
    LEROY, J
    BARDOS, P
    [J]. THROMBOSIS AND HAEMOSTASIS, 1991, 65 (06) : 1005 - 1005
  • [7] Anticardiolipin antibodies in systemic lupus erythematosus
    Pizov, AV
    Levin, VN
    Demidova, NA
    [J]. JOURNAL OF RHEUMATOLOGY, 2001, 28 : 40 - 40
  • [8] ANTICARDIOLIPIN ANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS
    Ben Salem, T.
    Naceur, I.
    Tougorti, M.
    Lamloum, M.
    Ben Ghorbel, I.
    Houman, M. H.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2017, 76 : 1238 - 1238
  • [9] Portal vein thrombosis in systemic lupus erythematosus associated with anticardiolipin antibodies
    Cavallasca, Javier A.
    Musuruana, Jorge L.
    Granero, Gonzalo
    [J]. INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 2011, 14 (01) : E5 - E7
  • [10] Anti-BB′-Sm antibodies, anticardiolipin antibodies, and thrombosis in systemic lupus erythematosus
    López-Longo, FJ
    Monteagudo, I
    González, CM
    Moreno, AC
    Mahou, MR
    Grau, R
    Carreño, L
    [J]. JOURNAL OF RHEUMATOLOGY, 1998, 25 (09) : 1743 - 1749