The presence of anti-phosphatidylserine/prothrombin antibodies as risk factor for both arterial and venous thrombosis in patients with systemic lupus erythematosus

被引：1
|
作者：
Nojima, Junzo [1 ]
Iwatani, Yoshinori [2 ]
Suehisa, Etsuji [1 ]
Kuratsune, Hirohiko [3 ]
Kanakura, Yuzuru [4 ]
机构：
[1] Osaka Univ Hosp, Lab Clin Invest, Suita, Osaka 5650871, Japan
[2] Osaka Univ, Div Biomed Informat, Course Hlth Sci, Grad Sch Med, Suita, Osaka, Japan
[3] Kansai Univ Welf Sci, Fac Hlth Sci Welf, Dept Hlth Sci, Osaka 5820026, Japan
[4] Osaka Univ, Dept Hematol & Oncol, Grad Sch Med, Suita, Osaka, Japan
来源：
HAEMATOLOGICA | 2006年 / 91卷 / 05期
关键词：
anti-phospholipid antibodies; systemic lupus erythematosus; anti-beta 2-glycoprotein I antibodies; anti-phosphatidylserine/prothrombin antibodies;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In an effort to clarify the clinical significance of anti-phospholipid antibodies (aPL) detected by enzyme-linked immunosorbent assay (ELISA), we examined the prevalence of anti-cardiolipin antibodies (aCL), anti-beta 2-glycoprotein I antibodies (anti-beta 2-GPI), anti-prothrombin antibodies (anti-PT), and anti-phosphatidylserine/prothrombin antibodies (anti-PS/PT) in 175 patients with systemic lupus erythematosus (SLE) comprising 67 patients with thrombotic complications. The present study showed that positive results of anti-beta 2-GPI-ELISA and anti-PS/PT-ELISA could serve as markers of thrombotic complications in patients with SLE, whereas aCL and anti-PT are less reliable as markers of these complications. Furthermore, results of the anti-PS/PT-ELISA correlate best with the occurrence of both arterial and venous thrombosis in patients with SLE.
引用
收藏
页码：699 / 702
页数：4
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