Graphene oxide: A carbocatalyst for the one-pot multicomponent synthesis of highly functionalized tetrahydropyridines

被引：24
|
作者：
Gupta, Annah [1 ]
Kaur, Ramneet [1 ]
Singh, Deepika [2 ]
Kapoor, Kamal K. [1 ]
机构：
[1] Univ Jammu, Dept Chem, Jammu 180006, India
[2] CSIR, Med Chem Div, Indian Inst Integrat Med, Canal Rd, Jammu 180001, India
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 26期
关键词：
Graphene oxide; Carbocatalyst; Multicomponent reaction; Tetrahydropyridine; Heterogeneous catalysis; One-pot reaction; GRAPHITE OXIDE; SUBSTITUTED PIPERIDINES; BETA-ENAMINONES; METAL-FREE; EFFICIENT; SOLVENT; DERIVATIVES; INHIBITORS; PYRIDINES; CHEMISTRY;
D O I：
10.1016/j.tetlet.2017.05.067
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple, straightforward and efficient methodology is described for the synthesis of polysubstituted tetrahydropyridine via one-pot multicomponent reaction of beta-ketoester, aldehyde and aniline in presence of catalytic amount of graphene oxide in acetonitrile. Graphene oxide is a versatile carbocatalyst and this is the first report on its application in a five component reaction. Good yield, usage of readily available starting material, operational simplicity, easy work-up and eco-friendly re-usable catalyst are the key features of this protocol. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2583 / 2587
页数：5
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