One-pot Multicomponent Synthesis of Highly Functionalized 1,4-Dihydropyridines Using Porcine Pancreatic Lipase

被引：0
|
作者：
Ling Jiang
Wenting Ye
Weike Su
机构：
[1] Zhejiang University of Technology,Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals
来源：
Chemical Research in Chinese Universities | 2019年 / 35卷
关键词：
lipase; Biocatalysis; One-pot synthesis; Higly functionalized 1,4-dihydropyridines;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of highly functionalized 1,4-dihydropyridines was synthesized via one-pot multicomponent reactions of aromatic aldehyde, malononitrile and N-methyl-1-(methylthio)-2-nitroethenamine using Porcine pancreatic lipase(PPL) as catalyst in DMSO. This protocol is featured by mild reaction conditions, simple operation and environmental acceptability.
引用
收藏
页码：235 / 238
页数：3
相关论文
共 50 条
  • [1] One-pot Multicomponent Synthesis of Highly Functionalized 1,4-Dihydropyridines Using Porcine Pancreatic Lipase
    Jiang Ling
    Ye Wenting
    Su Weike
    [J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2019, 35 (02) : 235 - 238
  • [2] One-Pot Multicomponent Reactions for the Efficient Synthesis of Highly Functionalized Dihydropyridines
    Pal, Suman
    Choudhury, Lokman H.
    Parvin, Tasneem
    [J]. SYNTHETIC COMMUNICATIONS, 2013, 43 (07) : 986 - 992
  • [3] One-pot synthesis and aromatization of 1,4-dihydropyridines in refluxing water
    Xia, JJ
    Wang, GW
    [J]. SYNTHESIS-STUTTGART, 2005, (14): : 2379 - 2383
  • [4] One-pot synthesis of 4-aryl-1,4-dihydropyridines in water
    Shi, DQ
    Mou, J
    Zhuang, QY
    Wang, XS
    Tu, SJ
    [J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2004, 24 (09) : 1042 - 1044
  • [5] A catalytic and green method for one-pot synthesis of new Hantzsch 1,4-dihydropyridines
    Ahmed Majeed Jassem
    Faeza Abdul Kareem Almashal
    Mohammed Qasim Mohammed
    Hadi Abdal Samad Jabir
    [J]. SN Applied Sciences, 2020, 2
  • [6] Synthesis of functionalized 1,4-dihydropyridines containing benzosultams catalyzed by lipase
    Xu, Yuelin
    Li, Fengxi
    Tang, Yong
    Wu, Junhao
    Wang, Chunyu
    Du, Chuang
    Wang, Zhi
    Wang, Lei
    [J]. NEW JOURNAL OF CHEMISTRY, 2023, 47 (20) : 9708 - 9713
  • [7] A catalytic and green method for one-pot synthesis of new Hantzsch 1,4-dihydropyridines
    Jassem, Ahmed Majeed
    Almashal, Faeza Abdul Kareem
    Mohammed, Mohammed Qasim
    Jabir, Hadi Abdal Samad
    [J]. SN APPLIED SCIENCES, 2020, 2 (03)
  • [8] One-pot, three-component synthesis of highly substituted pyridines and 1,4-dihydropyridines by using nanocrystalline magnesium oxide
    M. Lakshmi Kantam
    Koosam Mahendar
    Suresh Bhargava
    [J]. Journal of Chemical Sciences, 2010, 122 : 63 - 69
  • [9] One-pot, three-component synthesis of highly substituted pyridines and 1,4-dihydropyridines by using nanocrystalline magnesium oxide
    Kantam, M. Lakshmi
    Mahendar, Koosam
    Bhargava, Suresh
    [J]. JOURNAL OF CHEMICAL SCIENCES, 2010, 122 (01): : 63 - 69
  • [10] DPTA-catalyzed one-pot regioselective synthesis of polysubstituted pyridines and 1,4-dihydropyridines
    Li, Jianjun
    He, Ping
    Yu, Chuanming
    [J]. TETRAHEDRON, 2012, 68 (22) : 4138 - 4144
12345