One-pot Multicomponent Synthesis of Highly Functionalized 1,4-Dihydropyridines Using Porcine Pancreatic Lipase

被引：0
|
作者：
Ling Jiang
Wenting Ye
Weike Su
机构：
[1] Zhejiang University of Technology,Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals
来源：
Chemical Research in Chinese Universities | 2019年 / 35卷
关键词：
lipase; Biocatalysis; One-pot synthesis; Higly functionalized 1,4-dihydropyridines;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of highly functionalized 1,4-dihydropyridines was synthesized via one-pot multicomponent reactions of aromatic aldehyde, malononitrile and N-methyl-1-(methylthio)-2-nitroethenamine using Porcine pancreatic lipase(PPL) as catalyst in DMSO. This protocol is featured by mild reaction conditions, simple operation and environmental acceptability.
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页码：235 / 238
页数：3
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