Synthesis of Functionalized 1-Benzamido-1,4-dihydropyridines via a One-Pot Two-Step Four-Component Reaction

被引：12
|
作者：
Sun, Jing [1 ]
Shen, Guoliang [1 ]
Xie, Yajing [1 ]
Yan, Chaoguo [1 ]
机构：
[1] Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2014年 / 32卷 / 11期
基金：
中国国家自然科学基金;
关键词：
one-pot reaction; multicomponent reaction; 1; 4-dihydropyridine; benzohydrazide; electron-deficient alkyne; DIELS-ALDER REACTION; MULTICOMPONENT SYNTHESIS; 3-COMPONENT REACTIONS; EFFICIENT SYNTHESIS; AROMATIC-ALDEHYDES; DOMINO REACTIONS; DIASTEREOSELECTIVE SYNTHESIS; RECYCLABLE CATALYST; FACILE SYNTHESIS; ARYLAMINES;
D O I：
10.1002/cjoc.201400437
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The one-pot four-component reaction of benzohydrazide, acetylenedicarboxylate, aromatic aldehydes and malononitrile in ethanol with triethylamine as base catalyst afforded functionalized 1-benzamido-1,4-dihydropyridines in satisfactory yields. Under similar conditions, picolinohydrazide or nicotinohydrazide can also be successfully utilized in the reactions to give corresponding functionalized 1,4-dihydropyridines. H-1 NMR data indicated that an equilibrium of cis/trans-conformations exist in 1-benzamido-1,4-dihydropyridines.
引用
收藏
页码：1143 / 1150
页数：8
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