Graphene oxide: A carbocatalyst for the one-pot multicomponent synthesis of highly functionalized tetrahydropyridines

被引：24

作者：

Gupta, Annah ^{[1
]}

Kaur, Ramneet ^{[1
]}

Singh, Deepika ^{[2
]}

Kapoor, Kamal K. ^{[1
]}

机构：

[1] Univ Jammu, Dept Chem, Jammu 180006, India

[2] CSIR, Med Chem Div, Indian Inst Integrat Med, Canal Rd, Jammu 180001, India

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 26期

关键词：

Graphene oxide; Carbocatalyst; Multicomponent reaction; Tetrahydropyridine; Heterogeneous catalysis; One-pot reaction; GRAPHITE OXIDE; SUBSTITUTED PIPERIDINES; BETA-ENAMINONES; METAL-FREE; EFFICIENT; SOLVENT; DERIVATIVES; INHIBITORS; PYRIDINES; CHEMISTRY;

D O I：

10.1016/j.tetlet.2017.05.067

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, straightforward and efficient methodology is described for the synthesis of polysubstituted tetrahydropyridine via one-pot multicomponent reaction of beta-ketoester, aldehyde and aniline in presence of catalytic amount of graphene oxide in acetonitrile. Graphene oxide is a versatile carbocatalyst and this is the first report on its application in a five component reaction. Good yield, usage of readily available starting material, operational simplicity, easy work-up and eco-friendly re-usable catalyst are the key features of this protocol. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：2583 / 2587

页数：5

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