Organic Catalytic Multicomponent One-Pot Synthesis of Highly Substituted Pyrroles

被引：8
|
作者：
Jing, Xiaobi [1 ]
Pan, Xin [1 ]
Li, Zhen [1 ]
Bi, Xiaoxin [1 ]
Yan, Chaoguo [1 ]
Zhu, Hongxiang [2 ]
机构：
[1] Yangzhou Univ, Coll Chem & Chem Engn, Dept Chem, Yangzhou 225002, Jiangsu, Peoples R China
[2] Guangxi Univ, Sch Light Ind & Food Engn, Nanning 530004, Guangxi, Peoples R China
来源：
SYNTHETIC COMMUNICATIONS | 2009年 / 39卷 / 21期
基金：
中国国家自然科学基金;
关键词：
Highly substituted pyrroles; Paal-Knorr reaction; thiazolium salts catalysts; INSERTION; MECHANISM; SYSTEMS;
D O I：
10.1080/00397910902838953
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A multicomponent synthesis of highly substituted pyrroles catalyzed by thiazolium salts has been disclosed. The reaction employs an acyl anion conjugate addition reaction of aldegyde and unsaturated ketones to generate 1,4-dicarbonyl compounds in situ. The subsequent addition of various amines promotes a Paal-Knorr reaction, affording the desired pyrrole nucleus in an efficient one-pot process.
引用
收藏
页码：3833 / 3844
页数：12
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