Palladium-Catalyzed Aerobic Oxidative Cross-Coupling Reactions of Terminal Alkynes with Alkylzinc Reagents

被引：118

作者：

Chen, Mao ^{[1
]}

Zheng, Xiaolong ^{[1
]}

Li, Wenqing ^{[1
]}

He, Jun ^{[1
]}

Lei, Aiwen ^{[1
,2
]}

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China

[2] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 12期

基金：

中国国家自然科学基金;

关键词：

C-H BONDS; ARYL GRIGNARD-REAGENTS; MOLECULAR-OXYGEN; EFFICIENT SYNTHESIS; ORGANIC-CHEMICALS; ELECTRON-TRANSFER; ACTIVATION; FUNCTIONALIZATION; ARYLATION; ACIDS;

D O I：

10.1021/ja100630p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

With air as the oxidant, terminal alkynes can be directly cross-coupled with alkylzinc reagents in the presence of a Pd catalyst at room temperature. CO was found to be critical in gaining high chemical yields and selectivities. A wide range of alkynes and alkylzinc reagents were tested, and good to excellent yields were obtained.

引用

页码：4101 / +

页数：4

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