Polymorphisms in the Human Apolipoprotein E Receptor 2 Gene in Japanese Sporadic Alzheimer's Disease Patients

被引：3

作者：

Hosoda, Akemi ^{[1
]}

Inoue, Takashi ^{[2
]}

Mao, Chang C. ^{[3
]}

Jeong, Young-Hee ^{[1
]}

Yamagishi, Azumi ^{[1
]}

Ye, Mingjuan ^{[1
]}

Yamamoto, Tokuo ^{[3
]}

Kim, Dong-Ho ^{[1
]}

Saeki, Shigeru ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Human Life Sci, Sumiyoshi Ku, Osaka 5588585, Japan

[2] Brain Sci Inst, Lab Dev Neurobiol, Wako, Saitama 3510198, Japan

[3] Tohoku Univ, Inst Dev Aging & Canc, Ctr Adv Genome Res, Aoba Ku, Sendai, Miyagi 9818555, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2010年 / 74卷 / 03期

关键词：

Alzheimer's disease; apoE receptor 2; polymorphisms; DENSITY-LIPOPROTEIN RECEPTOR; VLDL RECEPTOR; ASSOCIATION; EXPRESSION; BINDING; ALLELE; BRAIN;

D O I：

10.1271/bbb.90857

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apolipoprotein E (apoE) polymorphism is associated with onset of Alzheimer's disease (AD). We found seven polymorphisms in apoE receptor 2 (ApoER2), an apoEbinding receptor, in Japanese sporadic AD patients, but no association of ApoER2 polymorphisms with AD. We consider that the functions of ApoER2 in the brain may be compensated for by those of other apoE-binding receptors such as VLDL receptor.

引用

页码：677 / 679

页数：3

共 50 条

[41] The alternative splicing of the apolipoprotein E gene is unperturbed in the brains of Alzheimer’s disease patients
James D. Mills
Pamela J. Sheahan
Donna Lai
Jillian J. Kril
Michael Janitz
Greg T. Sutherland
Molecular Biology Reports, 2014, 41 : 6365 - 6376
[42] Apolipoprotein E gene polymorphism in Indian patients with Alzheimer's disease and vascular dementia
Luthra, K
Tripathi, M
Grover, R
Dwivedi, M
Kumar, A
Dey, AB
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2004, 17 (03) : 132 - 135
[43] The alternative splicing of the apolipoprotein E gene is unperturbed in the brains of Alzheimer's disease patients
Mills, James D.
Sheahan, Pamela J.
Lai, Donna
Kril, Jillian J.
Janitz, Michael
Sutherland, Greg T.
MOLECULAR BIOLOGY REPORTS, 2014, 41 (10) : 6365 - 6376
[44] No evidence of association between apolipoprotein E gene regulatory region polymorphism and Alzheimer's disease in Japanese
M. Kimura
S. Matsushita
H. Arai
T. Matsui
T. Yuzuriha
S. Higuchi
Journal of Neural Transmission, 2000, 107 : 1449 - 1456
[45] Polymorphisms of the apolipoprotein E gene regulatory region and of the LDL receptor gene in late-onset Alzheimer's disease in relation to the plasma lipidic pattern
Scacchi, R
Gambina, G
Martini, MC
Ruggeri, M
Ferrari, G
Silvestri, M
Schiavon, R
Corbo, RM
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2001, 12 (02) : 63 - 68
[46] A study on gene polymorphisms related to sporadic Alzheimer's disease among Chinese
Wang, LN
Wang, L
Wu, DB
Ye, L
Liu, JW
NEUROBIOLOGY OF AGING, 2004, 25 : S516 - S516
[47] Dinucleotide repeat polymorphisms in the neprilysin gene are not associated with sporadic Alzheimer's disease
Oda, M
Morino, H
Maruyama, H
Terasawa, H
Izumi, Y
Torii, T
Sasaki, K
Nakamura, S
Kawakami, H
NEUROSCIENCE LETTERS, 2002, 320 (1-2) : 105 - 107
[48] Apolipoprotein E and methylenetetrahydrofolate reductase polymorphisms in Chinese elderly with Alzheimer's disease
Liu, JW
Ye, L
Wu, DB
Wang, L
Wang, LN
NEUROBIOLOGY OF AGING, 2002, 23 (01) : S339 - S339
[49] Polymorphisms in the human apolipoprotein-J/clusterin gene: Ethnic variation and distribution in Alzheimer's disease
Tycko, B
Feng, L
Nguyen, L
Francis, A
Hays, A
Chung, WY
Tang, MX
Stern, Y
Sahota, A
Hendrie, H
Mayeux, R
HUMAN GENETICS, 1996, 98 (04) : 430 - 436
[50] Interleukin-6 receptor gene polymorphisms were associated with sporadic Alzheimer's disease in Chinese Han
Wang, Min
Song, Haiqing
Jia, Jianping
BRAIN RESEARCH, 2010, 1327 : 1 - 5

← 1 2 3 4 5 →