Polymorphisms in the Human Apolipoprotein E Receptor 2 Gene in Japanese Sporadic Alzheimer's Disease Patients

被引：3

作者：

Hosoda, Akemi ^{[1
]}

Inoue, Takashi ^{[2
]}

Mao, Chang C. ^{[3
]}

Jeong, Young-Hee ^{[1
]}

Yamagishi, Azumi ^{[1
]}

Ye, Mingjuan ^{[1
]}

Yamamoto, Tokuo ^{[3
]}

Kim, Dong-Ho ^{[1
]}

Saeki, Shigeru ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Human Life Sci, Sumiyoshi Ku, Osaka 5588585, Japan

[2] Brain Sci Inst, Lab Dev Neurobiol, Wako, Saitama 3510198, Japan

[3] Tohoku Univ, Inst Dev Aging & Canc, Ctr Adv Genome Res, Aoba Ku, Sendai, Miyagi 9818555, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2010年 / 74卷 / 03期

关键词：

Alzheimer's disease; apoE receptor 2; polymorphisms; DENSITY-LIPOPROTEIN RECEPTOR; VLDL RECEPTOR; ASSOCIATION; EXPRESSION; BINDING; ALLELE; BRAIN;

D O I：

10.1271/bbb.90857

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apolipoprotein E (apoE) polymorphism is associated with onset of Alzheimer's disease (AD). We found seven polymorphisms in apoE receptor 2 (ApoER2), an apoEbinding receptor, in Japanese sporadic AD patients, but no association of ApoER2 polymorphisms with AD. We consider that the functions of ApoER2 in the brain may be compensated for by those of other apoE-binding receptors such as VLDL receptor.

引用

页码：677 / 679

页数：3

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