Immunomagnetic reduction assay using high-Tc superconducting-quantum-interference-device-based magnetosusceptometry

被引：27
|
作者：
Chieh, J. J. [1 ]
Yang, Shieh-Yueh [1 ,2 ]
Horng, Herng-Er [1 ]
Yu, C. Y. [1 ]
Lee, C. L. [1 ,2 ]
Wu, H. L. [3 ]
Hong, Chin-Yih [4 ]
Yang, Hong-Chang [5 ]
机构：
[1] Natl Taiwan Normal Univ, Inst Electroopt Sci & Technol, Taipei 116, Taiwan
[2] MagQu Co Ltd, Sindian City 231, Taipei County, Taiwan
[3] Natl Cheng Kung Univ, Dept Biochem & Mol Biol, Tainan 701, Taiwan
[4] Natl Chung Hsing Univ, Grad Inst Biomed Engn, Taichung 402, Taiwan
[5] Natl Taiwan Univ, Dept Phys, Taipei 106, Taiwan
来源：
JOURNAL OF APPLIED PHYSICS | 2010年 / 107卷 / 07期
关键词：
MAGNETIC NANOPARTICLES; SQUID; IMMUNOASSAY;
D O I：
10.1063/1.3340861
中图分类号：
O59 [应用物理学];
学科分类号：
摘要：
Via immunomagnetic reduction assay, biomolecules can be quantitatively detected with aid of biofunctionalized magnetic nanoparticles, which are used as labeling markers for specific biomolecules. To achieve ultra-high sensitivity in detecting biomolecules, superconducting quantum interference device (SQUID) is a promising candidate to act as a sensor to the magnetic signal related to the concentration of detected biomolecules. In the past, we developed a single channel SQUID-based magnetosusceptometry. In order to increase the detection through-put, multichannel SQUID-based magnetosusceptometry is developed. In this work, the design and working principle of four-channel SQUID-based magnetosusceptometry are introduced. Using utilizing scanning technology, four samples can be simultaneously logged into the SQUID-based magnetosusceptometry. Notably, only single SQUID magnetometer is used in the magnetosusceptometry. The precision and sensitivity in detecting biomolecules using the four-channel SQUID-based magnetosusceptometry are investigated. (C) 2010 American Institute of Physics. [doi:10.1063/1.3340861]
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页数：5
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