Immunomagnetic reduction assay using high-Tc superconducting-quantum-interference-device-based magnetosusceptometry

被引：27

作者：

Chieh, J. J. ^{[1
]}

Yang, Shieh-Yueh ^{[1
,2
]}

Horng, Herng-Er ^{[1
]}

Yu, C. Y. ^{[1
]}

Lee, C. L. ^{[1
,2
]}

Wu, H. L. ^{[3
]}

Hong, Chin-Yih ^{[4
]}

Yang, Hong-Chang ^{[5
]}

机构：

[1] Natl Taiwan Normal Univ, Inst Electroopt Sci & Technol, Taipei 116, Taiwan

[2] MagQu Co Ltd, Sindian City 231, Taipei County, Taiwan

[3] Natl Cheng Kung Univ, Dept Biochem & Mol Biol, Tainan 701, Taiwan

[4] Natl Chung Hsing Univ, Grad Inst Biomed Engn, Taichung 402, Taiwan

[5] Natl Taiwan Univ, Dept Phys, Taipei 106, Taiwan

来源：

JOURNAL OF APPLIED PHYSICS | 2010年 / 107卷 / 07期

关键词：

MAGNETIC NANOPARTICLES; SQUID; IMMUNOASSAY;

D O I：

10.1063/1.3340861

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Via immunomagnetic reduction assay, biomolecules can be quantitatively detected with aid of biofunctionalized magnetic nanoparticles, which are used as labeling markers for specific biomolecules. To achieve ultra-high sensitivity in detecting biomolecules, superconducting quantum interference device (SQUID) is a promising candidate to act as a sensor to the magnetic signal related to the concentration of detected biomolecules. In the past, we developed a single channel SQUID-based magnetosusceptometry. In order to increase the detection through-put, multichannel SQUID-based magnetosusceptometry is developed. In this work, the design and working principle of four-channel SQUID-based magnetosusceptometry are introduced. Using utilizing scanning technology, four samples can be simultaneously logged into the SQUID-based magnetosusceptometry. Notably, only single SQUID magnetometer is used in the magnetosusceptometry. The precision and sensitivity in detecting biomolecules using the four-channel SQUID-based magnetosusceptometry are investigated. (C) 2010 American Institute of Physics. [doi:10.1063/1.3340861]

引用

页数：5

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