A novel ECL sensor for determination of carcinoembryonic antigen using reduced graphene Oxide-BaYF5:Yb, Er upconversion nanocomposites and gold nanoparticles

被引：29
|
作者：
Zhao, Linlin [1 ]
Li, Juan [1 ]
Liu, Yuhong [1 ]
Wei, Yuan [1 ]
Zhang, Jin [1 ]
Zhang, Jinzha [1 ]
Xia, Qing [1 ]
Zhang, Qiang [1 ]
Zhao, Wenbo [1 ]
Chen, Xiaoqiang [2 ]
机构：
[1] Nanjing Normal Univ, Coll Chem & Mat Sci, Jiangsu Key Lab Biofunct Mat, Nanjing 210023, Jiangsu, Peoples R China
[2] Nanjing Univ Technol, Coll Chem & Chem Engn, State Key Lab Mat Oriented Chem Engn, Nanjing 210009, Jiangsu, Peoples R China
来源：
SENSORS AND ACTUATORS B-CHEMICAL | 2016年 / 232卷
基金：
中国国家自然科学基金;
关键词：
Reduced graphene Oxide-BaYF5:Yb; Er nanocomposites; Surface assembly; Carcinoembryonic antigen; Electrochemiluminescence immunosensor; RESONANCE ENERGY-TRANSFER; ELECTROGENERATED CHEMILUMINESCENCE; QUANTUM DOTS; ULTRASENSITIVE DETECTION; ELECTROCHEMILUMINESCENCE; COMPOSITES; FLUORESCENCE; IMMUNOASSAY;
D O I：
10.1016/j.snb.2016.03.153
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
We reported a novel ECL immunosensor for detection of carcinoembryonic antigen (CEA) based on the reduced graphene Oxide-BaYF5:Yb, Er (rGO-BaYF5:Yb, Er) nanocomposites. The rGO-BaYF5:Yb, Er nanocomposites, used as electrode luminescence materials, were prepared by in situ hydrothermal method, and characterized by TEM, XRD, UV-vis spectra, and upconversion fluorescence spectra. Further, poly (diallyldimethylammonium chloride) (PDDA), Au nanoparticles (AuNPs), and Anti-CEA were successively assembled on the surface of rGO-BaYF5:Yb, Er nanocomposites modified-electrode for fabricating ECL immunosensor. The results of the ECL measurements of CEA indicated that this novel ECL immunosensor exhibited high sensitive response to CEA in a linear range of 0.001-80 ng mL(-1) with a low detection limit of 0.87 pgmL(-1), good selectivity and satisfactory stability. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：484 / 491
页数：8
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