A novel ECL sensor for determination of carcinoembryonic antigen using reduced graphene Oxide-BaYF5:Yb, Er upconversion nanocomposites and gold nanoparticles

被引：29

作者：

Zhao, Linlin ^{[1
]}

Li, Juan ^{[1
]}

Liu, Yuhong ^{[1
]}

Wei, Yuan ^{[1
]}

Zhang, Jin ^{[1
]}

Zhang, Jinzha ^{[1
]}

Xia, Qing ^{[1
]}

Zhang, Qiang ^{[1
]}

Zhao, Wenbo ^{[1
]}

Chen, Xiaoqiang ^{[2
]}

机构：

[1] Nanjing Normal Univ, Coll Chem & Mat Sci, Jiangsu Key Lab Biofunct Mat, Nanjing 210023, Jiangsu, Peoples R China

[2] Nanjing Univ Technol, Coll Chem & Chem Engn, State Key Lab Mat Oriented Chem Engn, Nanjing 210009, Jiangsu, Peoples R China

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2016年 / 232卷

基金：

中国国家自然科学基金;

关键词：

Reduced graphene Oxide-BaYF5:Yb; Er nanocomposites; Surface assembly; Carcinoembryonic antigen; Electrochemiluminescence immunosensor; RESONANCE ENERGY-TRANSFER; ELECTROGENERATED CHEMILUMINESCENCE; QUANTUM DOTS; ULTRASENSITIVE DETECTION; ELECTROCHEMILUMINESCENCE; COMPOSITES; FLUORESCENCE; IMMUNOASSAY;

D O I：

10.1016/j.snb.2016.03.153

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We reported a novel ECL immunosensor for detection of carcinoembryonic antigen (CEA) based on the reduced graphene Oxide-BaYF5:Yb, Er (rGO-BaYF5:Yb, Er) nanocomposites. The rGO-BaYF5:Yb, Er nanocomposites, used as electrode luminescence materials, were prepared by in situ hydrothermal method, and characterized by TEM, XRD, UV-vis spectra, and upconversion fluorescence spectra. Further, poly (diallyldimethylammonium chloride) (PDDA), Au nanoparticles (AuNPs), and Anti-CEA were successively assembled on the surface of rGO-BaYF5:Yb, Er nanocomposites modified-electrode for fabricating ECL immunosensor. The results of the ECL measurements of CEA indicated that this novel ECL immunosensor exhibited high sensitive response to CEA in a linear range of 0.001-80 ng mL(-1) with a low detection limit of 0.87 pgmL(-1), good selectivity and satisfactory stability. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：484 / 491

页数：8

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