A novel ECL sensor for determination of carcinoembryonic antigen using reduced graphene Oxide-BaYF5:Yb, Er upconversion nanocomposites and gold nanoparticles

被引：29
|
作者：
Zhao, Linlin [1 ]
Li, Juan [1 ]
Liu, Yuhong [1 ]
Wei, Yuan [1 ]
Zhang, Jin [1 ]
Zhang, Jinzha [1 ]
Xia, Qing [1 ]
Zhang, Qiang [1 ]
Zhao, Wenbo [1 ]
Chen, Xiaoqiang [2 ]
机构：
[1] Nanjing Normal Univ, Coll Chem & Mat Sci, Jiangsu Key Lab Biofunct Mat, Nanjing 210023, Jiangsu, Peoples R China
[2] Nanjing Univ Technol, Coll Chem & Chem Engn, State Key Lab Mat Oriented Chem Engn, Nanjing 210009, Jiangsu, Peoples R China
来源：
SENSORS AND ACTUATORS B-CHEMICAL | 2016年 / 232卷
基金：
中国国家自然科学基金;
关键词：
Reduced graphene Oxide-BaYF5:Yb; Er nanocomposites; Surface assembly; Carcinoembryonic antigen; Electrochemiluminescence immunosensor; RESONANCE ENERGY-TRANSFER; ELECTROGENERATED CHEMILUMINESCENCE; QUANTUM DOTS; ULTRASENSITIVE DETECTION; ELECTROCHEMILUMINESCENCE; COMPOSITES; FLUORESCENCE; IMMUNOASSAY;
D O I：
10.1016/j.snb.2016.03.153
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
We reported a novel ECL immunosensor for detection of carcinoembryonic antigen (CEA) based on the reduced graphene Oxide-BaYF5:Yb, Er (rGO-BaYF5:Yb, Er) nanocomposites. The rGO-BaYF5:Yb, Er nanocomposites, used as electrode luminescence materials, were prepared by in situ hydrothermal method, and characterized by TEM, XRD, UV-vis spectra, and upconversion fluorescence spectra. Further, poly (diallyldimethylammonium chloride) (PDDA), Au nanoparticles (AuNPs), and Anti-CEA were successively assembled on the surface of rGO-BaYF5:Yb, Er nanocomposites modified-electrode for fabricating ECL immunosensor. The results of the ECL measurements of CEA indicated that this novel ECL immunosensor exhibited high sensitive response to CEA in a linear range of 0.001-80 ng mL(-1) with a low detection limit of 0.87 pgmL(-1), good selectivity and satisfactory stability. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：484 / 491
页数：8
相关论文
共 50 条
  • [11] Amperometric sandwich immunoassay for the carcinoembryonic antigen using a glassy carbon electrode modified with iridium nanoparticles, polydopamine and reduced graphene oxide
    Miao, Luyang
    Jiao, Lei
    Zhang, Juan
    Li, He
    MICROCHIMICA ACTA, 2017, 184 (01) : 169 - 175
  • [12] Electrochemical immunosensor for the carcinoembryonic antigen based on a nanocomposite consisting of reduced graphene oxide, gold nanoparticles and poly(indole-6-carboxylic acid)
    Zhao, Dan
    Wang, Yang
    Nie, Guangming
    MICROCHIMICA ACTA, 2016, 183 (11) : 2925 - 2932
  • [13] Amperometric sandwich immunoassay for the carcinoembryonic antigen using a glassy carbon electrode modified with iridium nanoparticles, polydopamine and reduced graphene oxide
    Luyang Miao
    Lei Jiao
    Juan Zhang
    He Li
    Microchimica Acta, 2017, 184 : 169 - 175
  • [14] Determination of melamine in food contact materials using an electrode modified with gold nanoparticles and reduced graphene oxide
    Chen, Ningning
    Cheng, Yuxiao
    Li, Chen
    Zhang, Cuiling
    Zhao, Kai
    Xian, Yuezhong
    MICROCHIMICA ACTA, 2015, 182 (11-12) : 1967 - 1975
  • [15] Determination of melamine in food contact materials using an electrode modified with gold nanoparticles and reduced graphene oxide
    Ningning Chen
    Yuxiao Cheng
    Chen Li
    Cuiling Zhang
    Kai Zhao
    Yuezhong Xian
    Microchimica Acta, 2015, 182 : 1967 - 1975
  • [16] A novel aptasensor based on 3D-reduced graphene oxide modified gold nanoparticles for determination of arsenite
    Ensafi, Ali A.
    Akbarian, F.
    Heydari-Soureshjani, E.
    Rezaei, B.
    BIOSENSORS & BIOELECTRONICS, 2018, 122 : 25 - 31
  • [17] A novel lable-free electrochemical immunosensor for carcinoembryonic antigen based on gold nanoparticles-thionine-reduced graphene oxide nanocomposite film modified glassy carbon electrode
    Kong, Fen-Ying
    Xu, Mao-Tian
    Xu, Jing-Juan
    Chen, Hong-Yuan
    TALANTA, 2011, 85 (05) : 2620 - 2625
  • [18] A graphene quantum dots based electrochemiluminescence immunosensor for carcinoembryonic antigen detection using poly(5-formylindole)/reduced graphene oxide nanocomposite
    Nie, Guangming
    Wang, Yang
    Tang, Yun
    Zhao, Dan
    Guo, Qingfu
    BIOSENSORS & BIOELECTRONICS, 2018, 101 : 123 - 128
  • [19] A paper-based electrochemical immunosensor with reduced graphene oxide/thionine/gold nanoparticles nanocomposites modification for the detection of cancer antigen 125
    Fan, Yan
    Shi, Shengyu
    Ma, Junshuang
    Guo, Yaohua
    BIOSENSORS & BIOELECTRONICS, 2019, 135 : 1 - 7
  • [20] A Novel Electrochemical Sensor Based on Reduced Graphene Oxide-TiO2 Nanocomposites with High Selectivity for the Determination of Hydroxychloroquine
    Zhang, Huilan
    Cheng, Lu
    Shang, Hongyuan
    Zhang, Wen
    Zhang, Aiping
    RUSSIAN JOURNAL OF ELECTROCHEMISTRY, 2021, 57 (08) : 872 - 884
12345