GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo

被引：494
|
作者：
Bustelo, Xose R.
Sauzeau, Vincent
Berenjeno, Inmaculada M.
机构：
[1] Univ Salamanca, Ctr Invest Canc, E-37007 Salamanca, Spain
[2] Univ Salamanca, IBMCC, CSIC, E-37007 Salamanca, Spain
来源：
BIOESSAYS | 2007年 / 29卷 / 04期
关键词：
D O I：
10.1002/bies.20558
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Rho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. Although originally implicated in the control of cytoskeletal events, it is currently known that these GTPases coordinate diverse cellular functions, including cell polarity, vesicular trafficking, the cell cycle and transcriptomal dynamics. In this review, we will provide an overview on the recent advances in this field regarding the mechanism of regulation and signaling, and the roles in vivo of this important GTPase family.
引用
收藏
页码：356 / 370
页数：15
相关论文
共 50 条
  • [21] The GTP-binding protein Rho
    Ridley, AJ
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 1997, 29 (11): : 1225 - 1229
  • [22] Control of reorganization of the actin cytoskeleton by Rho family small GTP-binding proteins in yeast
    Tanaka, K
    Takai, Y
    CURRENT OPINION IN CELL BIOLOGY, 1998, 10 (01) : 112 - 116
  • [23] Regulation and modes of action of Ras and Rho small GTP-binding proteins in budding yeast
    Tanaka, K
    SEIKAGAKU, 1997, 69 (08): : 979 - 990
  • [24] Small GTP-binding Proteins and their Functions in Plants
    Qing-Hu Ma
    Journal of Plant Growth Regulation, 2007, 26 : 369 - 388
  • [25] Small GTP-binding proteins and their functions in plants
    Ma, Qing-Hu
    JOURNAL OF PLANT GROWTH REGULATION, 2007, 26 (04) : 369 - 388
  • [26] THE CELLULAR FUNCTIONS OF SMALL GTP-BINDING PROTEINS
    HALL, A
    SCIENCE, 1990, 249 (4969) : 635 - 640
  • [27] Association of the Rho family small GTP-binding proteins with Rho GDP dissociation inhibitor (Rho GDI) in Saccharomyces cerevisiae
    Koch, G
    Tanaka, K
    Masuda, T
    Yamochi, W
    Nonaka, H
    Takai, Y
    ONCOGENE, 1997, 15 (04) : 417 - 422
  • [28] Association of the Rho family small GTP-binding proteins with Rho GDP dissociation inhibitor (Rho GDI) in Saccharomyces cerevisiae
    Gertrude Koch
    Kazuma Tanaka
    Tadayuki Masuda
    Wataru Yamochi
    Hidetaro Nonaka
    Yoshimi Takai
    Oncogene, 1997, 15 : 417 - 422
  • [29] Regulation of small GTP-binding proteins by insulin
    Welsh, GI
    Hers, I
    Wherlock, M
    Tavaré, JM
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2006, 34 : 209 - 212
  • [30] A Process Model of Rho GTP-binding Proteins in the Context of Phagocytosis
    Cardelli, Luca
    Gardner, Philippa
    Kahramanogullari, Ozan
    ELECTRONIC NOTES IN THEORETICAL COMPUTER SCIENCE, 2008, 194 (03) : 87 - 102
12345