THE CELLULAR FUNCTIONS OF SMALL GTP-BINDING PROTEINS

被引：842
|
作者：
HALL, A
机构：
[1] Chester Beatty Laboratories, Institute of Cancer Research, London SW3 6JB, Fulham Road
来源：
SCIENCE | 1990年 / 249卷 / 4969期
关键词：
D O I：
10.1126/science.2116664
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A substantial number of novel guanine nucleotide binding regulatory proteins have been identified over the last few years but the function of many of them is largely unknown. This article will discuss a particular family of these proteins, structurally related to the Ras oncoprotein. Approximately 30 Ras-related small guanosine triphosphate (GTP)-binding proteins are known, and from yeast to man they appear to be involved in controlling a diverse set of essential cellular functions including growth, differentiation, cytoskeletal organization, and intracellular vesicle transport and secretion.
引用
收藏
页码：635 / 640
页数：6
相关论文
共 50 条
  • [1] Small GTP-binding Proteins and their Functions in Plants
    Qing-Hu Ma
    [J]. Journal of Plant Growth Regulation, 2007, 26 : 369 - 388
  • [2] Small GTP-binding proteins and their functions in plants
    Ma, Qing-Hu
    [J]. JOURNAL OF PLANT GROWTH REGULATION, 2007, 26 (04) : 369 - 388
  • [3] SMALL GTP-BINDING PROTEINS
    TAKAI, Y
    KAIBUCHI, K
    KIKUCHI, A
    KAWATA, M
    [J]. INTERNATIONAL REVIEW OF CYTOLOGY-A SURVEY OF CELL BIOLOGY, 1992, 133 : 187 - 230
  • [4] SMALL GTP-BINDING PROTEINS
    BURGOYNE, RD
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 1989, 14 (10) : 394 - 396
  • [5] Small GTP-binding proteins
    Takai, Y
    Sasaki, T
    Matozaki, T
    [J]. PHYSIOLOGICAL REVIEWS, 2001, 81 (01) : 153 - 208
  • [6] Influence of small GTP-binding proteins on cellular norepinephrine uptake
    Koch, G
    Hochkeppeler, I
    Szabo, B
    Hofmann, F
    [J]. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1998, 358 (01) : R652 - R652
  • [7] REQUIREMENT OF PRENYLATION OF SMALL GTP-BINDING PROTEINS FOR THEIR ACTIVATION AND FUNCTIONS
    TAKAI, Y
    KAIBUCHI, K
    KIKUCHI, A
    SASAKI, T
    SHIRATAKI, H
    TANAKA, K
    [J]. FASEB JOURNAL, 1993, 7 (07): : A1039 - A1039
  • [8] DIVERSE BIOLOGICAL FUNCTIONS OF SMALL GTP-BINDING PROTEINS IN YEAST
    BOTSTEIN, D
    SEGEV, N
    STEARNS, T
    HOYT, MA
    HOLDEN, J
    KAHN, RA
    [J]. COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1988, 53 : 629 - 636
  • [9] THE RAS SUPERFAMILY OF SMALL GTP-BINDING PROTEINS
    DOWNWARD, J
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 1990, 15 (12) : 469 - 472
  • [10] Regulation of small GTP-binding proteins by insulin
    Welsh, GI
    Hers, I
    Wherlock, M
    Tavaré, JM
    [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2006, 34 : 209 - 212
12345