A Process Model of Rho GTP-binding Proteins in the Context of Phagocytosis

被引：3

作者：

Cardelli, Luca ^{[1
]}

Gardner, Philippa ^{[2
]}

Kahramanogullari, Ozan ^{[3
]}

机构：

[1] Microsoft Res, 7 JJ Thomson Ave, Cambridge CB3 0FB, England

[2] Imperial Coll, Dept Comp, London, England

[3] Imperial Coll, Ctr Integrat Syst Biol, London, England

来源：

ELECTRONIC NOTES IN THEORETICAL COMPUTER SCIENCE | 2008年 / 194卷 / 03期

基金：

英国生物技术与生命科学研究理事会;

关键词：

phagocytosis; GTP-binding proteins; stochastic pi-calculus; process modeling;

D O I：

10.1016/j.entcs.2007.12.007

中图分类号：

TP301 [理论、方法];

学科分类号：

081202 ;

摘要：

At the early stages of the phagocytic signalling, Rho GTP-binding proteins play a key role. With the stimulus from the cell membrane and with the help from the regulators (GEF, GAP, Effector, GDI), these proteins serve as switches that interact with their environment in a complex manner. We present a generic process model for the Rho GTP-binding proteins, and compare it with a previous model that uses ordinary differential equations. We then extend the basic model to include the behaviour of the GDIs. We discuss the challenges this extension brings and directions of further research.

引用

页码：87 / 102

页数：16

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