Further new nardosinane-type sesquiterpenoids from the Xisha soft coral Litophyton nigrum

被引：6

作者：

Yang, Fan ^{[1
,2
,3
,4
]}

Hua, Qiang ^{[1
,3
]}

Yao, Li-Gong ^{[2
]}

Liang, Lin-Fu ^{[5
]}

Lu, Yan-Hua ^{[1
,3
]}

An, Fa-Liang ^{[1
,3
]}

Guo, Yue-Wei ^{[2
]}

机构：

[1] East China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hi Tech Pk, Shanghai 201203, Peoples R China

[3] Shanghai Collaborat Innovat Ctr Biomfg Technol, 130 Meilong Rd, Shanghai 200237, Peoples R China

[4] Shanghai Normal Univ, Coll Life & Environm Sci, Dept Biol, 100 Guilin Rd, Shanghai 200234, Peoples R China

[5] Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, 498 South Shaoshan Rd, Changsha 410004, Peoples R China

来源：

FITOTERAPIA | 2021年 / 151卷

基金：

中国国家自然科学基金;

关键词：

Soft coral; Litophyton nigrum; Nardosinane;

D O I：

10.1016/j.fitote.2021.104906

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Further chemical investigation of the Xisha soft coral Litophyton nigrum has resulted in the isolation of four new nardosinane-type sesquiterpenoids, namely linardosinenes D-G (1-4). The structures of new compounds were elucidated by extensive analyses of their spectroscopic data and by comparison with the reported data of known related ones. All compounds exhibited weak inhibitory effect against bromodomain-containing protein 4 (BRD4), a promising therapeutic target in various human diseases, at a concentration of 10 mu M.

引用

页数：4

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