4α-Methylated steroids with cytotoxic activity from the soft coral Litophyton mollis

被引：13

作者：

Koncic, Marijana Zovko ^{[1
,2
]}

Ioannou, Efstathia ^{[1
]}

Sawadogo, Wamtinga Richard ^{[3
]}

Abdel-Razik, Ayman F. ^{[4
]}

Vagias, Constantinos ^{[1
]}

Diederich, Marc ^{[3
,5
]}

Roussis, Vassilios ^{[1
]}

机构：

[1] Univ Athens, Dept Pharmacognosy & Chem Nat Prod, Fac Pharm, Athens 15771, Greece

[2] Univ Zagreb, Fac Pharm & Biochem, Zagreb 10000, Croatia

[3] LBMCC, Luxembourg, Luxembourg

[4] Natl Res Ctr, Nat Prod Chem Dept, Cairo 12622, Egypt

[5] Seoul Natl Univ, Dept Pharm, Coll Pharm, Seoul 151742, South Korea

来源：

STEROIDS | 2016年 / 115卷

关键词：

Litophyton mollis; 4 alpha-Methylated steroids; Structure elucidation; Cytotoxic activity; CHEMICAL-CONSTITUENTS; BIOLOGICAL-PROPERTIES; SIDE-CHAIN; DINOSTEROL; NEPHTHEA;

D O I：

10.1016/j.steroids.2016.08.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seven new (1-3, 5 and 8-10) and three previously reported (4, 6 and 7) 4 alpha-methylated steroids were isolated from the organic extract of the gorgonian Litophyton mollis. The structures and the relative configurations of the isolated natural products were determined on the basis of extensive analyses of their NMR and MS data. Metabolites 1 and 5-8 exhibited cytotoxic activity against K562 human chronic myelogenous leukemia cells with IC50 values below 10 mu M, while at the same time displaying low toxicity against healthy PBMCs. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：130 / 135

页数：6

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