Cytotoxic Oxygenated Steroids from the Soft Coral Nephthea erecta

被引：10
|
作者：
Tsai, Tsung-Chang [1 ,2 ]
Huang, Yu-Ting [3 ]
Chou, Shih-Kai [4 ]
Shih, Ming-Cheng [4 ]
Chiang, Ching-Ying [5 ]
Su, Jui-Hsin [6 ,7 ]
机构：
[1] Meiho Univ, Dept Food Sci & Nutr, Pingtung 912, Taiwan
[2] Meiho Univ, Dept Nursing, Pingtung 912, Taiwan
[3] I Shou Univ, Dept Nutr, Kaohsiung 824, Taiwan
[4] I Shou Univ, Dept Biol Sci & Technol, Kaohsiung 824, Taiwan
[5] Natl Kaohsiung Marine Univ, Ctr Gen Studies, Kaohsiung 811, Taiwan
[6] Natl Dong Hwa Univ, Grad Inst Marine Biol, Pingtung 944, Taiwan
[7] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2016年 / 64卷 / 10期
关键词：
10-demethylated steroid; soft coral; Nephthea erecta; cytotoxicity; 19-OXYGENATED STEROIDS; CHABROLII;
D O I：
10.1248/cpb.c16-00426
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new 10-demethylated steroid, nephtheasteroid A (1), a new 19-oxygenated steroid, nephtheasteroid B (2) as well as five known steroids 3-7 were isolated from the organic extract of a Taiwanese soft coral Neplztlzea erecta. The structure was determined by means of IR, MS, and NMR techniques. Among these metabolites, 1 is rarely found in steroids possessing a 19-norergostane skeleton. In vitro cytotoxicity study using 3-(4,5-dimethylthiazol-2-y1)-2,5-diphenyltetrazolium bromide (MTT) assay revealed that compounds 3 and 4 exhibited cytotoxicity against human chronic myelogenous leukemia (K562), human acute lymphoblastic leukemia (Molt-4), human T lymphoblastoid (Sup-T1), and human leukemic monocyte lymphoma (U937), with IC50 of 6.5-14.0 mu m.
引用
收藏
页码：1519 / 1522
页数：4
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