Mammalian single-strand break repair: Mechanisms and links with chromatin

被引：118
|
作者：
Caldecott, Keith W. [1 ]
机构：
[1] Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England
来源：
DNA REPAIR | 2007年 / 6卷 / 04期
基金：
英国医学研究理事会;
关键词：
chromatin; base excision repair; XRCCI; PARP; DNA strand break repair;
D O I：
10.1016/j.dnarep.2006.10.006
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Thousands of cellular single-strand breaks (SSBs) arise in cells each day, from attack of deoxyribose and DNA bases by reactive oxygen species and other electrophilic molecules, and from the intrinsic instability of DNA. If not repaired, SSBs can disrupt transcription and replication and can be converted into potentially clastogenic and/or lethal DNA double-strand breaks. Here, I present an updated model for the repair of SSBs, and speculate on the possible impact of chromatin structure and remodelling on single-strand break repair (SSBR) processes. (c) 2006 Published by Elsevier B.V.
引用
收藏
页码：443 / 453
页数：11
相关论文
共 50 条
  • [41] EFFECT OF EXTREME HYPOXIA ON REPAIR OF DNA SINGLE-STRAND BREAKS IN MAMMALIAN-CELLS
    KOCH, CJ
    PAINTER, RB
    RADIATION RESEARCH, 1975, 64 (02) : 256 - 269
  • [42] Efficiency of repair of DNA single-strand breaks correlates with life span of mammalian species
    Bürkle, A
    Leake, A
    Müller, M
    Kirkwood, TB
    Pfeiffer, R
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2004, 369 : R126 - R126
  • [43] Mutations in hamster single-strand break repair gene XRCC1 causing defective DNA repair
    Shen, NR
    Zdzienicka, MZ
    Mohrenweiser, H
    Thompson, LH
    Thelen, MP
    NUCLEIC ACIDS RESEARCH, 1998, 26 (04) : 1032 - 1037
  • [44] Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells
    Nassour, Joe
    Martien, Bastien
    Martin, Nathalie
    Deruy, Emeric
    Tomellini, Elisa
    Malaquin, Nicolas
    Bouali, Fatima
    Sabatier, Laure
    Wernert, Nicolas
    Pinte, Sebastien
    Gilson, Eric
    Pourtier, Albin
    Pluquet, Olivier
    Abbadie, Corinne
    NATURE COMMUNICATIONS, 2016, 7
  • [45] Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells
    Joe Nassour
    Sébastien Martien
    Nathalie Martin
    Emeric Deruy
    Elisa Tomellini
    Nicolas Malaquin
    Fatima Bouali
    Laure Sabatier
    Nicolas Wernert
    Sébastien Pinte
    Eric Gilson
    Albin Pourtier
    Olivier Pluquet
    Corinne Abbadie
    Nature Communications, 7
  • [46] Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1
    Sherif F. El-Khamisy
    Gulam M. Saifi
    Michael Weinfeld
    Fredrik Johansson
    Thomas Helleday
    James R. Lupski
    Keith W. Caldecott
    Nature, 2005, 434 : 108 - 113
  • [47] TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo
    Katyal, Sachin
    El-Khamisy, Sherif F.
    Russell, Helen R.
    Li, Yang
    Ju, Limei
    Caldecott, Keith W.
    McKinnon, Peter J.
    EMBO JOURNAL, 2007, 26 (22): : 4720 - 4731
  • [48] Short-patch single-strand break repair in ataxia oculomotor apraxia-1
    Reynolds, John J.
    El-Khamisy, Sherif F.
    Caldecott, Keith W.
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2009, 37 : 577 - 581
  • [49] Chromosomal single-strand break repair and neurological disease: Implications on transcription and emerging genomic tools
    Abugable, Arwa A.
    Antar, Sarah
    El-Khamisy, Sherif F.
    DNA REPAIR, 2024, 135
  • [50] Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1
    El-Khamisy, SF
    Saifi, GM
    Weinfeld, M
    Johansson, F
    Helleday, T
    Lupski, JR
    Caldecott, KW
    NATURE, 2005, 434 (7029) : 108 - 113
12345