Mammalian single-strand break repair: Mechanisms and links with chromatin

被引：118
|
作者：
Caldecott, Keith W. [1 ]
机构：
[1] Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England
来源：
DNA REPAIR | 2007年 / 6卷 / 04期
基金：
英国医学研究理事会;
关键词：
chromatin; base excision repair; XRCCI; PARP; DNA strand break repair;
D O I：
10.1016/j.dnarep.2006.10.006
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Thousands of cellular single-strand breaks (SSBs) arise in cells each day, from attack of deoxyribose and DNA bases by reactive oxygen species and other electrophilic molecules, and from the intrinsic instability of DNA. If not repaired, SSBs can disrupt transcription and replication and can be converted into potentially clastogenic and/or lethal DNA double-strand breaks. Here, I present an updated model for the repair of SSBs, and speculate on the possible impact of chromatin structure and remodelling on single-strand break repair (SSBR) processes. (c) 2006 Published by Elsevier B.V.
引用
收藏
页码：443 / 453
页数：11
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