Solubility of Ibuprofen Sodium Dihydrate in Acetone plus Water Mixtures: Experimental Measurement and Thermodynamic Modeling

被引：14
|
作者：
Dun, Weiqiang [1 ]
Wu, Songgu [1 ]
Tang, Weiwei [1 ]
Wang, Xuemei [1 ]
Sun, Dengqiong [1 ]
Du, Shichao [1 ]
Gong, Junbo [1 ,2 ,3 ]
机构：
[1] Tianjin Univ, State Key Lab Chem Engn, Tianjin 300072, Peoples R China
[2] Tianjin Univ, Coinnovat Ctr Chem & Chem Engn Tianjin, Tianjin 300072, Peoples R China
[3] Tianjin Univ, Tianjin Key Lab Modern Drug Delivery & High Effic, Tianjin 300072, Peoples R China
来源：
JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2014年 / 59卷 / 11期
基金：
中国国家自然科学基金;
关键词：
BINARY SOLVENTS; PURE SOLVENTS; BENZOIC-ACID; HYDROCHLORIDE; SOLVATION;
D O I：
10.1021/je5004093
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
The solubility of ibuprofen sodium dihydrate (ISD) in acetone + water mixtures was measured by the gravimetric method at temperatures ranging from (279.55 to 312.05) K. The measured solubilities were correlated by the modified Apelblat equation, the lambda h (Buchowski) equation, the vant Hoff model, the combined nearly ideal binary solvent/RedlichKister (CNIBS/R-K) equation, and the general single model. The modified Apelblat equation was the best model for correlating the solubility of ISD, while the general single model fits the best for mixed solvents. The standard enthalpy, entropy, and Gibbs energy of the dissociation process of ISD were calculated by the vant Hoff equation and the modified Apelblat model. In addition, there was a maximum value of solubility at a certain acetone mole fraction in the acetone + water mixture.
引用
收藏
页码：3415 / 3421
页数：7
相关论文
共 50 条
  • [31] Thermodynamic study of the solubility of sulfapyridine in some ethanol plus water mixtures
    Delgado, Daniel R.
    Rodriguez, Gerson A.
    Martinez, Fleming
    JOURNAL OF MOLECULAR LIQUIDS, 2013, 177 : 156 - 161
  • [32] Experimental investigation of the solubility of CO2 in (acetone plus water)
    Joedecke, Michael
    Kamps, Alvaro Perez-Salado
    Maurer, Gerd
    JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2007, 52 (03): : 1003 - 1009
  • [33] Thermodynamic analysis of the solubility of triclocarban in ethylene glycol plus water mixtures
    Maria Cruz-Gonzalez, Ana
    Sofia Vargas-Santana, Martha
    de Jesus Polania-Orozco, Sebastian
    Patricia Ortiz, Claudia
    Enrique Cerquera, Nestor
    Martinez, Fleming
    Ricardo Delgado, Daniel
    Jouyban, Abolghasem
    Acree, William E., Jr.
    JOURNAL OF MOLECULAR LIQUIDS, 2021, 325
  • [34] Thermodynamic analysis of the solubility of naproxen in ethanol plus water cosolvent mixtures
    Pacheco, Diana P.
    Martinez, Fleming
    PHYSICS AND CHEMISTRY OF LIQUIDS, 2007, 45 (05) : 581 - 595
  • [35] Solubility and Thermodynamic Analysis of Isotretinoin in Different (DMSO plus Water) Mixtures
    Shakeel, Faiyaz
    Haq, Nazrul
    Alshehri, Sultan
    Alenazi, Miteb
    Alwhaibi, Abdulrahman
    Alsarra, Ibrahim A.
    MOLECULES, 2023, 28 (20):
  • [36] Solubility correlation and thermodynamic analysis of solution of tylosin tartrate in methanol plus tetrahydrofuran or acetone) mixtures
    Shen, Yanmin
    Liu, Zhenfeng
    Zhi, Juanjuan
    Li, Tao
    Ren, Baozeng
    JOURNAL OF MOLECULAR LIQUIDS, 2015, 203 : 131 - 136
  • [37] Measurement and mathematical modeling of ketoconazole solubility in propylene glycol plus water mixtures at various temperatures
    Zadaliasghar, Samira
    Rahimpour, Elaheh
    Ghafourian, Taravat
    Martinez, Fleming
    Barzegar-Jalali, Mohammad
    Jouyban, Abolghasem
    JOURNAL OF MOLECULAR LIQUIDS, 2019, 291
  • [38] Solubility of benzoic acid in acetone, 2-propanol, acetic acid and cyclohexane: Experimental measurement and thermodynamic modeling
    Long, Bingwen
    Li, Jing
    Zhang, Rongrong
    Wan, Li
    FLUID PHASE EQUILIBRIA, 2010, 297 (01) : 113 - 120
  • [39] SOLUBILITY OF SODIUM DIHYDROGENOPHOSPHATE AND MONOHYDROGENOPHOSPHATE IN WATER-ACETONE-SODIUM PERCHLORATE MIXTURES AT 25 DEGREESC
    FERRONI, G
    GALEA, J
    ANTONETTI, G
    BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE PARTIE I-PHYSICOCHIMIE DES SYSTEMES LIQUIDES ELECTROCHIMIE CATALYSE GENIE CHIMIQUE, 1974, (12): : 2731 - 2734
  • [40] Measurement and Correlation Solubility of Sodium Succinate in Binary Mixed Solvents of Water plus (Methanol or Ethanol) Mixtures
    Cao, Zheng
    Hu, Yonghong
    Li, Jiaojiao
    Liang, Mengmeng
    Liu, Yan
    Yang, Wenge
    JOURNAL OF SOLUTION CHEMISTRY, 2014, 43 (05) : 821 - 835
12345