Solubility of Ibuprofen Sodium Dihydrate in Acetone plus Water Mixtures: Experimental Measurement and Thermodynamic Modeling

被引：14
|
作者：
Dun, Weiqiang [1 ]
Wu, Songgu [1 ]
Tang, Weiwei [1 ]
Wang, Xuemei [1 ]
Sun, Dengqiong [1 ]
Du, Shichao [1 ]
Gong, Junbo [1 ,2 ,3 ]
机构：
[1] Tianjin Univ, State Key Lab Chem Engn, Tianjin 300072, Peoples R China
[2] Tianjin Univ, Coinnovat Ctr Chem & Chem Engn Tianjin, Tianjin 300072, Peoples R China
[3] Tianjin Univ, Tianjin Key Lab Modern Drug Delivery & High Effic, Tianjin 300072, Peoples R China
来源：
JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2014年 / 59卷 / 11期
基金：
中国国家自然科学基金;
关键词：
BINARY SOLVENTS; PURE SOLVENTS; BENZOIC-ACID; HYDROCHLORIDE; SOLVATION;
D O I：
10.1021/je5004093
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
The solubility of ibuprofen sodium dihydrate (ISD) in acetone + water mixtures was measured by the gravimetric method at temperatures ranging from (279.55 to 312.05) K. The measured solubilities were correlated by the modified Apelblat equation, the lambda h (Buchowski) equation, the vant Hoff model, the combined nearly ideal binary solvent/RedlichKister (CNIBS/R-K) equation, and the general single model. The modified Apelblat equation was the best model for correlating the solubility of ISD, while the general single model fits the best for mixed solvents. The standard enthalpy, entropy, and Gibbs energy of the dissociation process of ISD were calculated by the vant Hoff equation and the modified Apelblat model. In addition, there was a maximum value of solubility at a certain acetone mole fraction in the acetone + water mixture.
引用
收藏
页码：3415 / 3421
页数：7
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