Synthesis, and biological evaluation of some 4-thiazolidinones

被引：0
|
作者：
Amir, M [1 ]
Azam, F [1 ]
机构：
[1] Hamdard Univ, Fac Pharm, Dept Pharmaceut Chem, New Delhi 110062, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2004年 / 14卷 / 02期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis and biological activities (antiinflammatory, antibacterial and antifungal) of a number of 2,3-substituted 4-thiazolidinone derivatives are described. The compounds showed antiinflammatory activity ranging from 61.53% to 83.07% whereas reference drug ibuprofen showed 83.07% inhibition at 100 mg/kg oral dose in this test. All these compounds showed significant antibacterial and antifungal activity when compared with standard drugs amikacin and fluconazole.
引用
收藏
页码：119 / 122
页数：4
相关论文
共 50 条
  • [31] Efficient microwave enhanced synthesis of 4-thiazolidinones
    Gududuru, V
    Nguyen, V
    Dalton, JT
    Miller, DD
    SYNLETT, 2004, (13) : 2357 - 2358
  • [32] Preparation methods, reactivity and biological importance of 4-thiazolidinones
    Liesen, Andre P.
    de Aquino, Thiago M.
    Goes, Alexandre J. S.
    de Lima, Jose G.
    de Faria, Antonio R.
    Alves, Antonio J.
    QUIMICA NOVA, 2008, 31 (02): : 369 - 376
  • [33] Synthesis, in-silico Studies and Evaluation of Anticancer Activity of Some Novel Benzothiazole Substituted 4-Thiazolidinones
    Shetty, Chaithra Raju
    Bhat, Katte Ishwar
    Kumar, Abhishek
    Kumar, Pankaj
    Krishnamurthy, Praveen Thaggikuppe
    Merugumolu, Vijay Kumar
    INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, 2020, 54 (04) : 1121 - 1132
  • [34] Synthesis of Mannich bases of some 2,5-disubstituted 4-thiazolidinones and evaluation of their antimicrobial activities
    Kocabalkanli, A
    Ates, Ö
    Ötük, G
    ARCHIV DER PHARMAZIE, 2001, 334 (02) : 35 - 39
  • [35] Synthesis of Mannich bases of some 2,5-disubstituted 4-thiazolidinones and evaluation of their antimicrobial activities
    Altintas, H
    Ates, O
    Birteksöz, S
    Ötük, G
    Uzun, M
    Satana, D
    TURKISH JOURNAL OF CHEMISTRY, 2005, 29 (04) : 425 - 435
  • [36] An Insight into 4-Thiazolidinones
    Sahu, Smriti
    Upadhyay, Prabhat Kumar
    Mishra, Pradeep
    JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL, 2021, 33 (45B) : 162 - 174
  • [37] PREPARATION OF SOME 4-THIAZOLIDINONES AS POSSIBLE ANTIMICROBIAL AGENTS
    JOSHI, MD
    JANI, MK
    SHAH, BR
    UNDAVIA, NK
    TRIVEDI, PB
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1990, 67 (11) : 925 - 927
  • [38] SYNTHESIS AND ANTIMICROBIAL ACTIVITY EVALUATION OF NOVEL 4-THIAZOLIDINONES CONTAINING A PYRONE MOIETY
    Nechak, Rosa
    Bouzroura, Samia Aichouche
    Benmalek, Yamina
    Salhi, Lydia
    Martini, Sophie P.
    Morizur, Vincent
    Dunach, Elisabet
    Kolli, Bellara Nedjar
    SYNTHETIC COMMUNICATIONS, 2015, 45 (02) : 262 - 272
  • [39] 4-thiazolidinones: Synthesis and effect of chloro substituent on fungitoxicity
    Upma, JR
    Manrao, MR
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2004, 14 (02) : 177 - 178
  • [40] Structural design, synthesis and pharmacological evaluation of 4-thiazolidinones against Trypanosoma cruzi
    de Oliveira Filho, Gevanio Bezerra
    de Oliveira Cardoso, Marcos Verissimo
    Pontes Espindola, Jose Wanderlan
    Gomes Rebello Ferreira, Luiz Felipe
    de Simone, Carlos Alberto
    Ferreira, Rafaela Salgado
    Coelho, Pollyanne Lacerda
    Meira, Cassio Santana
    Magalhaes Moreira, Diogo Rodrigo
    Pereira Soares, Milena Botelho
    Lima Leite, Ana Cristina
    BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 23 (23) : 7478 - 7486
12345