Synthesis of some novel cyanopyridines and isoxazoles bearing sulphonamide moiety and their antimicrobial activity

被引：0
|
作者：
Patel, VB [1 ]
Sorathiya, SD [1 ]
Parikh, AR [1 ]
机构：
[1] Saurashtra Univ, Dept Chem, Rajkot 360005, Gujarat, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1997年 / 36卷 / 09期
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D O I：
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Substituted 2-propen-1-ones 2a-h, prepared by the reaction of p-(2,5-dichlorobenzenesulphonamido)acetophenone 1 with araldehydes, on condensation with malononitrile in the presence of ammonium accetate yield cyanopyridines 3a-h. Also 2a-h on reaction with hydroxylamine hydrochloride in the presence of sodium acetate in acetic acid afford isoxazoles 4a-h. The structures of 3a-h and 4a-h have been established on the basis of elemental analyses and spectral (IR, H-1 NMR and mass) data. The products have been screened for their antimicrobial activity against various strains of bacteria and fungi.
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页码：822 / 825
页数：4
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