Synthesis of some novel cyanopyridines and isoxazoles bearing sulphonamide moiety and their antimicrobial activity

被引：0

作者：

Patel, VB ^{[1
]}

Sorathiya, SD ^{[1
]}

Parikh, AR ^{[1
]}

机构：

[1] Saurashtra Univ, Dept Chem, Rajkot 360005, Gujarat, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1997年 / 36卷 / 09期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Substituted 2-propen-1-ones 2a-h, prepared by the reaction of p-(2,5-dichlorobenzenesulphonamido)acetophenone 1 with araldehydes, on condensation with malononitrile in the presence of ammonium accetate yield cyanopyridines 3a-h. Also 2a-h on reaction with hydroxylamine hydrochloride in the presence of sodium acetate in acetic acid afford isoxazoles 4a-h. The structures of 3a-h and 4a-h have been established on the basis of elemental analyses and spectral (IR, H-1 NMR and mass) data. The products have been screened for their antimicrobial activity against various strains of bacteria and fungi.

引用

页码：822 / 825

页数：4

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