Synthesis of Indole-2-methylsulfonamides by Domino Sonogashira Coupling and Hydroamination Reaction

被引：5
|
作者：
Debnath, Sudarshan [1 ,2 ]
Malakar, Suniti [1 ,2 ]
Mondal, Shovan [1 ,2 ]
机构：
[1] Syamsundar Coll, Dept Chem, Shyamsundar 713424, India
[2] Visva Bharati Univ, Dept Chem, Santini Ketan 731235, W Bengal, India
来源：
CHEMISTRYSELECT | 2017年 / 2卷 / 10期
关键词：
Domino reaction; Hydroamination reaction; Indole; Sonogashira coupling; Sulfonamide; PALLADIUM-CATALYZED SYNTHESIS; ELECTROPHILIC CYCLIZATION; REGIOSELECTIVE SYNTHESIS; HETEROANNULATION REACTION; PROPARGYLIC AMINES; HECK CYCLIZATION; FUSED SULTONES; INDOLES; COPPER; 2-(AMINOMETHYL)INDOLES;
D O I：
10.1002/slct.201700544
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A domino Sonogashira coupling and hydroamination reaction between o-iodo-N, N-dimethylaniline derivatives and propargyl sulfonamides are described. This protocol allows access to a variety of indole-2-methylsulfonamides in good to excellent yields. The structures of the synthesized compounds are confirmed by XRD studies.
引用
收藏
页码：3147 / 3151
页数：5
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