Synthesis of Quinolino[3′,4′:4,5] pyrrolo[1,2-f]phenanthridines by Regioselective Sonogashira Reaction Followed by Domino C-N Coupling/Hydroamination/C-H Arylation

被引：9

作者：

Ngo Nghia Pham ^{[1
,2
,3
]}

Salman, Ghazwan Ali ^{[1
,4
]}

Ponce, Marian Blanco ^{[1
]}

Tuan Thanh Dang ^{[1
,3
]}

Spannenberg, Anke ^{[2
]}

Ehlers, Peter ^{[1
,2
]}

Langer, Peter ^{[1
,2
]}

机构：

[1] Univ Rostock, Inst Chem, Albert Einstein Str 3A, D-18059 Rostock, Germany

[2] Univ Rostock eV, Leibniz Inst Katalyse, Albert Einstein Str 29A, D-18059 Rostock, Germany

[3] VNU Univ Sci Hanoi VNU HUS, Fac Chem, 19 Le Thanh Tong, Hanoi, Vietnam

[4] Univ Al Mustansiriyah, Coll Sci, Dept Chem, Palestine St, Baghdad, Iraq

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 2017卷 / 26期

关键词：

Heterocycles; Palladium; Cyclization; Homogeneous catalysis; Domino reactions; COMPLEXES;

D O I：

10.1002/ejoc.201700371

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An effective and atom-economic synthesis of quinolino[3',4':4,5] pyrrolo[1,2-f] phenanthridines has been developed. The protocol involves a site-selective Sonogashira reaction of 3,4-dihaloquinoline, followed by a domino C-N coupling/hydroamination/C-H arylation reaction. Quinolino[3',4':4,5]pyrrolo[1,2-f] phenanthridines represent a hitherto unknown class of heterocyclic compounds.

引用

页码：3865 / 3873

页数：9

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