(2S,3R)-2-aminododecan-3-ol, a new antifungal agent from the ascidian Clavelina oblonga

被引：55
|
作者：
Kossuga, MH
MacMillan, JB
Rogers, EW
Molinski, TF
Nascimento, GGF
Rocha, RM
Berlinck, RGS
机构：
[1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil
[2] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA
[3] Univ Metodista Piracicaba, Fac Ciencias Saude, BR-13400901 Piracicaba, SP, Brazil
[4] Univ Fed Parana, Dept Zool, Setor Ciencias Biol, BR-81531990 Curitiba, Parana, Brazil
来源：
JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 11期
关键词：
D O I：
10.1021/np049782q
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new antifungal agent, (2S,3R)-2-aminododecan-3-ol (1), has been isolated from the ascidian Clavelina oblonga collected in Brazil. The structure of 1 was established by analysis of spectroscopic data, including absolute stereochemistry determined by circular dichroism analysis of the dibenzoyl derivative 2. Compound 1 displayed antifungal activity against Candida albicans ATCC 10231 with a MIC of 0.7 mug/ mL and against Candida glabrata with a MIC of 30 mug/mL.
引用
收藏
页码：1879 / 1881
页数：3
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