(2S,3R)-2-aminododecan-3-ol, a new antifungal agent from the ascidian Clavelina oblonga

被引：55

作者：

Kossuga, MH

MacMillan, JB

Rogers, EW

Molinski, TF

Nascimento, GGF

Rocha, RM

Berlinck, RGS

机构：

[1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil

[2] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

[3] Univ Metodista Piracicaba, Fac Ciencias Saude, BR-13400901 Piracicaba, SP, Brazil

[4] Univ Fed Parana, Dept Zool, Setor Ciencias Biol, BR-81531990 Curitiba, Parana, Brazil

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 11期

关键词：

D O I：

10.1021/np049782q

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new antifungal agent, (2S,3R)-2-aminododecan-3-ol (1), has been isolated from the ascidian Clavelina oblonga collected in Brazil. The structure of 1 was established by analysis of spectroscopic data, including absolute stereochemistry determined by circular dichroism analysis of the dibenzoyl derivative 2. Compound 1 displayed antifungal activity against Candida albicans ATCC 10231 with a MIC of 0.7 mug/ mL and against Candida glabrata with a MIC of 30 mug/mL.

引用

页码：1879 / 1881

页数：3

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