Limonoids from Aphanamixis polystachya Leaves and Their Interaction with Hsp90

被引：14

作者：

Camero, Cesar Munoz ^{[1
]}

Vassallo, Antonio ^{[2
]}

De Leo, Marinella ^{[1
,3
]}

Temraz, Abeer ^{[4
,5
]}

De Tommasi, Nunziatina ^{[6
]}

Braca, Alessandra ^{[1
,3
]}

机构：

[1] Univ Pisa, Dipartimento Farm, Pisa, Italy

[2] Univ Basilicata, Dipartimento Sci, Potenza, Italy

[3] Univ Pisa, Ctr Interdipartimentale Ric Nutraceut & Alimentaz, Pisa, Italy

[4] Umm Al Qura Univ, Dept Pharmacognosy, Fac Pharm, Mecca, Saudi Arabia

[5] Al Azhar Univ, Fac Pharm, Cairo, Egypt

[6] Univ Salerno, Dipartimento Farm, Via Giovanni Paolo 2 132, I-84084 Fisciano, SA, Italy

来源：

PLANTA MEDICA | 2018年 / 84卷 / 12-13期

关键词：

Aphanamixis polystachya; Meliaceae; limonoids; surface plasmon resonance; Hsp90; STEM BARK; KHAYANOLIDES; DERIVATIVES;

D O I：

10.1055/a-0624-9538

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A phytochemical study of n-hexane, CHCl3, and CHCl3-MeOH extracts of Aphanamixis polystachya leaves led to the isolation of 10 compounds. Five of them turned out to be new natural compounds, including two mexicanolide-type (1, 2) and three polyoxyphragmalin-type (3-5) limonoids, together with two known andirobin-type limonoids (6, 7) and three phenolic derivatives. The structures of the new compounds were established on the basis of spectroscopic methods to be 8-hydro-14,15-en-cabralin (1), 3-deacetyl-8-hydro-cabralin- 14,15-en-3-one (2), 20,22-dihydroxy-21,23-dimethoxytetrahydrofuran khayanolide A (3), 1-deacetyl-3-dehydroxy3- oxokhaysenelide E (4), and meliaphanamixin A (5). All compounds were isolated for the first time from this species. The ability of the isolated limonoids to interact with the molecular chaperone Hsp90 was tested. Compounds 6 and 7 were the most active.

引用

页码：964 / 970

页数：7

共 50 条

[41] Modulators of HSP90
不详
NATURE REVIEWS DRUG DISCOVERY, 2010, 9 (06) : 425 - 425
[42] NEW GLYCOSIDES FROM THE STEM BARK OF APHANAMIXIS-POLYSTACHYA
SRIVASTAVA, SK
AGNIHOTRI, VK
CURRENT SCIENCE, 1985, 54 (01): : 38 - 40
[43] Functional and physical interaction between yeast Hsp90 and Hsp70
Kravats, Andrea N.
Hoskins, Joel R.
Reidy, Michael
Johnson, Jill L.
Doyle, Shannon M.
Genest, Olivier
Masison, Daniel C.
Wickner, Sue
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (10) : E2210 - E2219
[44] Interaction of cepharanthine with immobilized heat shock protein 90α (Hsp90α) and screening of Hsp90α inhibitors (vol 434, pg 202, 2013)
Haginaka, Jun
Kitabatake, Tomoko
Hirose, Iyo
Matsunaga, Hisami
Moaddel, Ruin
ANALYTICAL BIOCHEMISTRY, 2013, 436 (02) : 65 - 65
[45] The Distinct Assignments for Hsp90α and Hsp90β: More Than Skin Deep
Chang, Cheng
Tang, Xin
Woodley, David T.
Chen, Mei
Li, Wei
CELLS, 2023, 12 (02)
[46] Unraveling Hsp90 and nitrated Hsp90 interactome in nervous system tumors
Adrita, Nirbachita
Manivannan, Bhagyashree
Claassen, Inge
Paul, Patience Ngozi
Szentirmai, Oszkar Szentirmai
Franco, Maria Clara
FREE RADICAL BIOLOGY AND MEDICINE, 2024, 224
[47] Effect of geldanamycin on transcription of Hsp90α and Hsp90β genes in brain of goldfish
Morishige, Kota
Kagawa, Nao
ZOOLOGICAL SCIENCE, 2006, 23 (12) : 1212 - 1212
[48] Hsp90: From Cellular to Organismal Proteostasis
Somogyvari, Milan
Khatatneh, Saba
Soti, Csaba
CELLS, 2022, 11 (16)
[49] Chaperone Activity and Dimerization Properties of Hsp90α and Hsp90β in Glucocorticoid Receptor Activation by the Multiprotein Hsp90/Hsp70-Dependent Chaperone Machinery
Morishima, Yoshihiro
Mehta, Ranjit K.
Yoshimura, Miyako
Lau, Miranda
Southworth, Daniel R.
Lawrence, Theodore S.
Pratt, William B.
Nyati, Mukesh K.
Osawa, Yoichi
MOLECULAR PHARMACOLOGY, 2018, 94 (03) : 984 - 991
[50] Evidence for interaction between Hsp90 and the ER membrane complex
Tambudzai Kudze
Carlos Mendez-Dorantes
Chernoh Sallieu Jalloh
Amie J. McClellan
Cell Stress and Chaperones, 2018, 23 : 1101 - 1115

← 1 2 3 4 5 →