Limonoids from Aphanamixis polystachya Leaves and Their Interaction with Hsp90

被引：14
|
作者：
Camero, Cesar Munoz [1 ]
Vassallo, Antonio [2 ]
De Leo, Marinella [1 ,3 ]
Temraz, Abeer [4 ,5 ]
De Tommasi, Nunziatina [6 ]
Braca, Alessandra [1 ,3 ]
机构：
[1] Univ Pisa, Dipartimento Farm, Pisa, Italy
[2] Univ Basilicata, Dipartimento Sci, Potenza, Italy
[3] Univ Pisa, Ctr Interdipartimentale Ric Nutraceut & Alimentaz, Pisa, Italy
[4] Umm Al Qura Univ, Dept Pharmacognosy, Fac Pharm, Mecca, Saudi Arabia
[5] Al Azhar Univ, Fac Pharm, Cairo, Egypt
[6] Univ Salerno, Dipartimento Farm, Via Giovanni Paolo 2 132, I-84084 Fisciano, SA, Italy
来源：
PLANTA MEDICA | 2018年 / 84卷 / 12-13期
关键词：
Aphanamixis polystachya; Meliaceae; limonoids; surface plasmon resonance; Hsp90; STEM BARK; KHAYANOLIDES; DERIVATIVES;
D O I：
10.1055/a-0624-9538
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A phytochemical study of n-hexane, CHCl3, and CHCl3-MeOH extracts of Aphanamixis polystachya leaves led to the isolation of 10 compounds. Five of them turned out to be new natural compounds, including two mexicanolide-type (1, 2) and three polyoxyphragmalin-type (3-5) limonoids, together with two known andirobin-type limonoids (6, 7) and three phenolic derivatives. The structures of the new compounds were established on the basis of spectroscopic methods to be 8-hydro-14,15-en-cabralin (1), 3-deacetyl-8-hydro-cabralin- 14,15-en-3-one (2), 20,22-dihydroxy-21,23-dimethoxytetrahydrofuran khayanolide A (3), 1-deacetyl-3-dehydroxy3- oxokhaysenelide E (4), and meliaphanamixin A (5). All compounds were isolated for the first time from this species. The ability of the isolated limonoids to interact with the molecular chaperone Hsp90 was tested. Compounds 6 and 7 were the most active.
引用
收藏
页码：964 / 970
页数：7
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