Limonoids from Aphanamixis polystachya Leaves and Their Interaction with Hsp90

被引：14

作者：

Camero, Cesar Munoz ^{[1
]}

Vassallo, Antonio ^{[2
]}

De Leo, Marinella ^{[1
,3
]}

Temraz, Abeer ^{[4
,5
]}

De Tommasi, Nunziatina ^{[6
]}

Braca, Alessandra ^{[1
,3
]}

机构：

[1] Univ Pisa, Dipartimento Farm, Pisa, Italy

[2] Univ Basilicata, Dipartimento Sci, Potenza, Italy

[3] Univ Pisa, Ctr Interdipartimentale Ric Nutraceut & Alimentaz, Pisa, Italy

[4] Umm Al Qura Univ, Dept Pharmacognosy, Fac Pharm, Mecca, Saudi Arabia

[5] Al Azhar Univ, Fac Pharm, Cairo, Egypt

[6] Univ Salerno, Dipartimento Farm, Via Giovanni Paolo 2 132, I-84084 Fisciano, SA, Italy

来源：

PLANTA MEDICA | 2018年 / 84卷 / 12-13期

关键词：

Aphanamixis polystachya; Meliaceae; limonoids; surface plasmon resonance; Hsp90; STEM BARK; KHAYANOLIDES; DERIVATIVES;

D O I：

10.1055/a-0624-9538

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A phytochemical study of n-hexane, CHCl3, and CHCl3-MeOH extracts of Aphanamixis polystachya leaves led to the isolation of 10 compounds. Five of them turned out to be new natural compounds, including two mexicanolide-type (1, 2) and three polyoxyphragmalin-type (3-5) limonoids, together with two known andirobin-type limonoids (6, 7) and three phenolic derivatives. The structures of the new compounds were established on the basis of spectroscopic methods to be 8-hydro-14,15-en-cabralin (1), 3-deacetyl-8-hydro-cabralin- 14,15-en-3-one (2), 20,22-dihydroxy-21,23-dimethoxytetrahydrofuran khayanolide A (3), 1-deacetyl-3-dehydroxy3- oxokhaysenelide E (4), and meliaphanamixin A (5). All compounds were isolated for the first time from this species. The ability of the isolated limonoids to interact with the molecular chaperone Hsp90 was tested. Compounds 6 and 7 were the most active.

引用

页码：964 / 970

页数：7

共 50 条

[21] From Conformation to Interaction: Techniques to Explore the Hsp70/Hsp90 Network
Batista, Fernanda A. H.
Gava, Lisandra M.
Pinheiro, Glyucia M. S.
Ramos, Carlos H. I.
Borges, Julio C.
CURRENT PROTEIN & PEPTIDE SCIENCE, 2015, 16 (08) : 735 - 753
[22] A New Limonoid from the seed of Aphanamixis polystachya
Hua Ping ZHANG
ChineseChemicalLetters, 2002, (04) : 341 - 342
[23] Overview: Translating Hsp90 Biology into Hsp90 Drugs
Workman, Paul
CURRENT CANCER DRUG TARGETS, 2003, 3 (05) : 297 - 300
[24] A comparison of Hsp90α and Hsp90β interactions with cochaperones and substrates
Taherian, Aliakbar
Krone, Patrick H.
Ovsenek, Nick
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 2008, 86 (01): : 37 - 45
[25] Two new triterpenoids from the fruits of Aphanamixis polystachya
Wu, Shi-Li
Zou, Qiu-Ping
Xie, Xiao-Yan
Ren, Jia-Jia
Fan, Zhang
OuYang, Jing-Rong
Yin, Peng-Cheng
Dong, Fa-Wu
He, Hong-Ping
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2022, 24 (08) : 738 - 745
[26] Limonoids from Guarea guidonia and Cedrela odorata: Heat Shock Protein 90 (Hsp90) Modulator Properties of Chisomicine D
Bellone, Maria Laura
Camero, Cesar Munoz
Chini, Maria Giovanna
Dal Piaz, Fabrizio
Hernandez, Vanessa
Bifulco, Giuseppe
De Tommasi, Nunziatina
Braca, Alessandra
JOURNAL OF NATURAL PRODUCTS, 2021, 84 (03): : 724 - 737
[27] A NOVEL MONOCLONAL ANTIRABBIT HSP90 ANTIBODY - USEFULNESS FOR STUDIES ON HSP90 STEROID-RECEPTOR INTERACTION
RADANYI, C
LOMBES, M
RENOIR, JM
DELAHAYE, F
BAULIEU, EE
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1992, 42 (08): : 863 - 874
[28] Hsp90: from structure to phenotype
Jackson, SE
Queitsch, C
Toft, D
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2004, 11 (12) : 1152 - 1155
[29] Hsp90: from structure to phenotype
Sophie E Jackson
Christine Queitsch
David Toft
Nature Structural & Molecular Biology, 2004, 11 : 1152 - 1155
[30] Study of Hsp90α and Hsp90β role in virus replication using cell lines with Hsp90 gene knockouts
Bieganowski, Pawel
Dalidowska, Iga
Gazi, Olga
Guzowska, Magdalena
Przybylski, Maciej
VIRUS GENES, 2025,

← 1 2 3 4 5 →