Teuchamaedol A, a new neo-clerodane diterpenoid from the aerial parts of Teucrium chamaedrys

被引：1

作者：

Kurimoto, Shin-ichiro ^{[1
,2
]}

Wakabayashi, Koji ^{[1
]}

Sasaki, Yu F. ^{[3
,4
]}

Nakamura, Takanori ^{[4
]}

Kubota, Takaaki ^{[1
,5
]}

机构：

[1] Showa Pharmaceut Univ, 3-3165 Higashi Tamagawagakuen, Machida, Tokyo 1948543, Japan

[2] Showa Univ, Sch Pharm, Shinagawa Ku, 1-5-8 Hatanodai, Tokyo 1428555, Japan

[3] Hachinohe Natl Coll Technol, Fac Chem & Biol Engn, Lab Genotoxic, 16-1 Tamonoki Uwanotai, Hachinohe, Aomori 0391192, Japan

[4] Himeji Dokkyo Univ, Fac Pharmaceut Sci, 7-2-1 Kamiohno, Himeji, Hyogo 6708524, Japan

[5] Okayama Univ, Fac Med Dent & Pharmaceut Sci, Kita Ku, 1-1-1 Tsushima Naka, Okayama 7008530, Japan

来源：

TETRAHEDRON LETTERS | 2022年 / 100卷

关键词：

neo-Clerodane; Diterpenoid; Teucrium chamaedrys; Lamiaceae; CLERODANE DITERPENOIDS; PORTULACA-GRANDIFLORA; GERMANDER; HEPATITIS;

D O I：

10.1016/j.tetlet.2022.153890

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new neo-clerodane diterpenoid, teuchamaedol A (1) was isolated from the EtOAc-soluble materials of the aerial parts of Teucrium chamaedrys. The structure of 1 was elucidated on the basis of spectral data. The absolute configuration of 1 was determined by modified Mosher's method. Teuchamaedol A (1) is the first neo-clerodane diterpenoid possessing a tetrahydrofuran moiety without additional oxygen function. (C) 2022 Elsevier Ltd. All rights reserved.

引用

页数：3

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