Teuchamaedol A, a new neo-clerodane diterpenoid from the aerial parts of Teucrium chamaedrys

被引：0
|
作者：
Kurimoto, Shin-ichiro [1 ,2 ]
Wakabayashi, Koji [1 ]
Sasaki, Yu F. [3 ,4 ]
Nakamura, Takanori [4 ]
Kubota, Takaaki [1 ,5 ]
机构：
[1] Showa Pharmaceut Univ, 3-3165 Higashi Tamagawagakuen, Machida, Tokyo 1948543, Japan
[2] Showa Univ, Sch Pharm, Shinagawa Ku, 1-5-8 Hatanodai, Tokyo 1428555, Japan
[3] Hachinohe Natl Coll Technol, Fac Chem & Biol Engn, Lab Genotoxic, 16-1 Tamonoki Uwanotai, Hachinohe, Aomori 0391192, Japan
[4] Himeji Dokkyo Univ, Fac Pharmaceut Sci, 7-2-1 Kamiohno, Himeji, Hyogo 6708524, Japan
[5] Okayama Univ, Fac Med Dent & Pharmaceut Sci, Kita Ku, 1-1-1 Tsushima Naka, Okayama 7008530, Japan
来源：
TETRAHEDRON LETTERS | 2022年 / 100卷
关键词：
neo-Clerodane; Diterpenoid; Teucrium chamaedrys; Lamiaceae; CLERODANE DITERPENOIDS; PORTULACA-GRANDIFLORA; GERMANDER; HEPATITIS;
D O I：
10.1016/j.tetlet.2022.153890
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new neo-clerodane diterpenoid, teuchamaedol A (1) was isolated from the EtOAc-soluble materials of the aerial parts of Teucrium chamaedrys. The structure of 1 was elucidated on the basis of spectral data. The absolute configuration of 1 was determined by modified Mosher's method. Teuchamaedol A (1) is the first neo-clerodane diterpenoid possessing a tetrahydrofuran moiety without additional oxygen function. (C) 2022 Elsevier Ltd. All rights reserved.
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页数：3
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