Synthesis and anti-inflammatory activity evaluation of some acridinyl amino antipyrine, acridinyl amino anthraquinone, acridino thiourea and thiazolino thiourea derivatives

9-Chloro-2(subsrituted)-acridines (I) on condensation with 4-amino antipyrine, 1-amino anthraquinone and 2-amino anthraquinone gave corresponding condensed products II, III and IV. Phenyl isothiocyanate reacts with 9- amino - 2 or 4 (substituted)-acridines (V) and iminothiazolines (VII) to give corresponding N-phenyl-N'- substituted thioureas VI and VIII in good yield. Anti-inflammatory activity screening for IIa, b, III, IV, VIb and VIIIa-I was carried our at 100 mg/kg p.o. and compounds IV, VIIIa, VIIIb and VIIIg-k showed 12, 12,14,18,7,23,13 and 18% activity whereas all others were found to be inactive. Analgesic activity screening for IIb, III and IV was carried out at 100mg/kg p.o.Only compound III showed 25% activity whereas IIb and IV were found to be inactive.