Synthesis, anti-inflammatory and antinociceptive activity of some novel benzothiazole derivatives

被引：0
|
作者：
Eman M. H. Abbas
Kamelia M. Amin
Wageeh S. El-Hamouly
Dina H. Dawood
Mohamed M. Abdalla
机构：
[1] National Research Center,Department of Chemistry of Natural and Microbial Products
[2] Cairo University,Department of Pharmaceutical Chemistry, Faculty of Pharmacy
[3] Saco Pharm. Co,Research Unit
来源：
Research on Chemical Intermediates | 2015年 / 41卷
关键词：
Benzothiazol-2-one; Benzothiazole; Anti-inflammatory; Antinocicepative;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A new series of derivatives bearing benzothiazol-2-one or benzothiazole ring system conjugated to other different heterocycles were prepared using 5,6-dimethoxy-3-benzothiazol-2(3H)-one (1) as a starting material. The structures of the newly synthesized products have been established based on analytical and spectral data. In addition, the anti-inflammatory and antinociceptive activities of some of the products were evaluated. Our data showed that many derivatives have promising activities as anti-inflammatory and antinocicepative agents.
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页码：2537 / 2555
页数：18
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