Synthesis and anti-inflammatory activity of some pyrazole derivatives

被引：0
|
作者：
Samir M. El-Moghazy
Flora F. Barsoum
Hamdy M. Abdel-Rahman
Adel A. Marzouk
机构：
[1] Cairo University,Faculty of Pharmacy, Pharmaceutical Chemistry Department
[2] Assiut University,Faculty of Pharmacy, Medicinal Chemistry Department
[3] Al-Azhar University,Faculty of Pharmacy, Pharmaceutical Chemistry Department
[4] Assiut branch,undefined
来源：
Medicinal Chemistry Research | 2012年 / 21卷
关键词：
Anti-inflammatory activity; COX-2; Pyrazole; Synthesis; Oxadiazoles; 1,2,4-Triazoles;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A novel series of pyrazoles containing benzenesulfonamides, 1,3,4-oxadiazole-2-thiones, 4-substituted-1,2,4-triazole-3-thiones, and 2-substituted-1,3,4-thiadiazoles has been synthesized. Anti-inflammatory activity of some synthesized compounds was evaluated in vivo utilizing a standard acute carrageenan-induced paw edema method. The most active anti-inflammatory agents 3, 8f, and 10f were evaluated for ulcerogenic liability in rats compared to indomethacin and celecoxib as reference standards. Molecular modeling studies were initiated herein to validate the attained pharmacological data and provide understandable evidence for the observed anti-inflammatory behavior.
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页码：1722 / 1733
页数：11
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