SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF NOVEL PYRAZOLINE DERIVATIVES

A new series of Chalcones (2a-i) were prepared by reacting 9-anthraldehyde and substituted ketones in alcohol medium in presence of NaOH. The Chalcones undergoes selective cyclization with Benzhydrazide (1) in glacial acetic acid medium to yield the title compounds 1,3,5-trisubstituted Pyrazolines (3a-i). The new compounds were assigned on the basis of H-1-NMR, IR and Mass spectral data. The newly synthesized compounds were evaluated for In-Vitro anti-inflammatory activity by bovine serum and egg albumin method. Some of the tested compounds 3a, 3h, 3f showed promising activity against bovine serum albumin denaturation when compared to the standard diclofenac sodium.