Synthesis of some floctafenine derivatives of expected anti-inflammatory/analgesic activity

被引：3
|
作者：
Hegazy, GH [1 ]
Taher, A
El-Zaher, AA
机构：
[1] Cairo Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo, Egypt
[2] Cairo Univ, Fac Pharm, Dept Organ Chem, Cairo, Egypt
来源：
ARCHIV DER PHARMAZIE | 2005年 / 338卷 / 08期
关键词：
floctafenine; esters; antipyrine; anti-inflammatory/analgesic activity;
D O I：
10.1002/ardp.200400959
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
New derivatives related to floctafenine were synthesized and representative examples were screened for their anti-inflammatory and analgesic activities. All compounds tested were found to exhibit anti-inflammatory and analgesic activities and some were more potent than the references, floctafenine and indomethacin, in carragenan-induced rat's paw edema. None of the tested compounds showed an ulcerogenic effect on the P-benzoquinone-induced writhing test in mice.
引用
收藏
页码：378 / 384
页数：7
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